In-Kwon Kim
Overview
Explore the profile of In-Kwon Kim including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
555
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Recent Articles
1.
Deltex family E3 ligases specifically ubiquitinate the terminal ADP-ribose of poly(ADP-ribosyl)ation
Kelly M, Dietz C, Kasson S, Zhang Y, Holtzman M, Kim I
Biochem Biophys Res Commun
. 2024 May;
720:150101.
PMID: 38749191
Poly(ADP-ribose) polymerases (PARPs) are critical to regulating cellular activities, such as the response to DNA damage and cell death. PARPs catalyze a reversible post-translational modification (PTM) in the form of...
2.
Kato J, Yamashita S, Ishiwata-Endo H, Oka S, Yu Z, Liu C, et al.
bioRxiv
. 2023 Feb;
PMID: 36798189
ADP-ribosylation is a reversible reaction with ADP-ribosyltransferases catalyzing the forward reaction and ADP-ribose-acceptor hydrolases (ARHs) hydrolyzing the ADP-ribose acceptor bond. ARH2 is a member of the 39-kDa ARH family (ARH1-3),...
3.
Pourfarjam Y, Ma Z, Kim I
Biochem Biophys Res Commun
. 2022 Aug;
625:53-59.
PMID: 35947915
The novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2 or COVID-19) has caused a global pandemic. The SARS-CoV-2 RNA genome is replicated by a conserved "core" replication-transcription complex (RTC) containing...
4.
Moiani D, Link T, Brosey C, Katsonis P, Lichtarge O, Kim Y, et al.
Methods Enzymol
. 2021 Nov;
661:407-431.
PMID: 34776222
We present a Chemistry and Structure Screen Integrated Efficiently (CASSIE) approach (named for Greek prophet Cassandra) to design inhibitors for cancer biology and pathogenesis. CASSIE provides an effective path to...
5.
Kasson S, Dharmapriya N, Kim I
PLoS One
. 2021 Jun;
16(6):e0254022.
PMID: 34191856
ADP-ribosylation is a key post-translational modification that regulates a wide variety of cellular stress responses. The ADP-ribosylation cycle is maintained by writers and erasers. For example, poly(ADP-ribosyl)ation cycles consist of...
6.
Yang C, Jividen K, Kamata T, Dworak N, Oostdyk L, Remlein B, et al.
Nat Commun
. 2021 May;
12(1):2705.
PMID: 33976187
Androgen signaling through the androgen receptor (AR) directs gene expression in both normal and prostate cancer cells. Androgen regulates multiple aspects of the AR life cycle, including its localization and...
7.
Ma Z, Pourfarjam Y, Kim I
Protein Expr Purif
. 2021 May;
185:105894.
PMID: 33933612
The novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2 or COVID-19) has led to a world-wild pandemic. The replication of SARS-CoV-2 RNA genome involves the core replication-transcription complex (RTC, nsp12-nsp7-nsp8)...
8.
Pourfarjam Y, Ma Z, Kurinov I, Moss J, Kim I
J Biol Chem
. 2021 Apr;
296:100692.
PMID: 33894202
ADP-ribosylation is a reversible and site-specific post-translational modification that regulates a wide array of cellular signaling pathways. Regulation of ADP-ribosylation is vital for maintaining genomic integrity, and uncontrolled accumulation of...
9.
Hammel M, Rashid I, Sverzhinsky A, Pourfarjam Y, Tsai M, Ellenberger T, et al.
Nucleic Acids Res
. 2020 Dec;
49(1):306-321.
PMID: 33330937
The XRCC1-DNA ligase IIIα complex (XL) is critical for DNA single-strand break repair, a key target for PARP inhibitors in cancer cells deficient in homologous recombination. Here, we combined biophysical...
10.
Pourfarjam Y, Kasson S, Tran L, Ho C, Lim S, Kim I
Biochem Biophys Res Commun
. 2020 May;
527(3):818-823.
PMID: 32439163
Poly(ADP-ribosyl)ation (PARylation) regulates DNA damage response, chromatin structure, and cell-fate. Dynamic regulation of cellular PAR levels is crucial for the maintenance of genomic integrity and excessive cellular PAR activates a...