Ihor R Lemischka
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Explore the profile of Ihor R Lemischka including associated specialties, affiliations and a list of published articles.
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80
Citations
5506
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Recent Articles
1.
Fasano C, Dimos J, Ivanova N, Lowry N, Lemischka I, Temple S
Cell Stem Cell
. 2023 Jun;
30(6):904.
PMID: 37267919
No abstract available.
2.
Mazloom A, Xu H, Reig-Palou J, Vasileva A, Roman A, Mulero-Navarro S, et al.
Front Cell Dev Biol
. 2022 Jun;
10:820255.
PMID: 35652095
Characterization of pluripotent states, in which cells can both self-renew or differentiate, with the irreversible loss of pluripotency, are important research areas in developmental biology. Although microRNAs (miRNAs) have been...
3.
Sevilla A, Papatsenko D, Mazloom A, Xu H, Vasileva A, Unwin R, et al.
Front Cell Dev Biol
. 2021 Apr;
9:630067.
PMID: 33816475
Cell fate decisions during development are governed by multi-factorial regulatory mechanisms including chromatin remodeling, DNA methylation, binding of transcription factors to specific loci, RNA transcription and protein synthesis. However, the...
4.
Xu A, Huang M, Zhu D, Gingold J, Bazer D, Chang B, et al.
Front Genet
. 2021 Feb;
11:611823.
PMID: 33519915
Osteosarcoma is one of the most frequent common primary malignant tumors in childhood and adolescence. Long non-coding RNAs (lncRNAs) have been reported to regulate the initiation and progression of tumors....
5.
Daniel M, Sachs D, Bernitz J, Fstkchyan Y, Rapp K, Satija N, et al.
FEBS Lett
. 2019 Sep;
593(23):3266-3287.
PMID: 31557312
Transcription factor (TF)-based reprogramming of somatic tissues holds great promise for regenerative medicine. Previously, we demonstrated that the TFs GATA2, GFI1B, and FOS convert mouse and human fibroblasts to hemogenic...
6.
Su J, Zhu D, Huo Z, Gingold J, Ang Y, Tu J, et al.
Cell Rep
. 2019 Aug;
28(6):1400-1409.e4.
PMID: 31390555
A multitude of signals are coordinated to maintain self-renewal in embryonic stem cells (ESCs). To unravel the essential internal and external signals required for sustaining the ESC state, we expand...
7.
Gomes A, Kurochkin I, Chang B, Daniel M, Law K, Satija N, et al.
Cell Rep
. 2018 Dec;
25(10):2821-2835.e7.
PMID: 30517869
During development, hematopoietic stem and progenitor cells (HSPCs) arise from specialized endothelial cells by a process termed endothelial-to-hematopoietic transition (EHT). The genetic program driving human HSPC emergence remains largely unknown....
8.
Oncogenic role of SFRP2 in p53-mutant osteosarcoma development via autocrine and paracrine mechanism
Kim H, Yoo S, Zhou R, Xu A, Bernitz J, Yuan Y, et al.
Proc Natl Acad Sci U S A
. 2018 Nov;
115(47):E11128-E11137.
PMID: 30385632
Osteosarcoma (OS), the most common primary bone tumor, is highly metastatic with high chemotherapeutic resistance and poor survival rates. Using induced pluripotent stem cells (iPSCs) generated from Li-Fraumeni syndrome (LFS)...
9.
Katz S, Backeris P, Merck C, Suprun M, DSouza S, Bishop D, et al.
PLoS One
. 2018 Oct;
13(10):e0203597.
PMID: 30289930
Research in photobiology is currently limited by a lack of devices capable of delivering precise and tunable irradiation to cells in a high-throughput format. This limits researchers to using expensive...
10.
Papatsenko D, Waghray A, Lemischka I
Stem Cell Res
. 2018 May;
29:180-188.
PMID: 29727814
Embryonic stem cells (ESCs) can proliferate and self-renew, maintaining their pluripotency status in vitro for a long period of time. Pluripotent states of ESCs in vitro are supported by a...