Igor V Komarov
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Explore the profile of Igor V Komarov including associated specialties, affiliations and a list of published articles.
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58
Citations
378
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Recent Articles
1.
Hrebonkin A, Afonin S, Nikitjuka A, Borysov O, Leitis G, Babii O, et al.
Chemistry
. 2024 Feb;
30(22):e202400066.
PMID: 38366887
Photoisomerizable peptides are promising drug candidates in photopharmacology. While azobenzene- and diarylethene-containing photoisomerizable peptides have already demonstrated their potential in this regard, reports on the use of spiropyrans to photoregulate...
2.
Komarov I, Bugrov V, Cherednychenko A, Grygorenko O
Chem Rec
. 2023 Oct;
24(2):e202300276.
PMID: 37847887
In the field of chemistry, model compounds find extensive use for investigating complex objects. One prime example of such object is the protein-ligand supramolecular interaction. Prediction the enthalpic and entropic...
3.
Horbatok K, Makhnii T, Kosach V, Danko V, Kovalenko A, Fatiushchenkov S, et al.
J Vis Exp
. 2023 Oct;
(199).
PMID: 37843289
Photocontrolled, biologically active compounds are an emerging class of "smart" drug candidates. They provide additional safety in systemic chemotherapy due to their precise spatiotemporal activation by directing a benign, non-ionizable...
4.
Pottie E, Poulie C, Simon I, Harpsoe K, DAndrea L, Komarov I, et al.
ACS Chem Neurosci
. 2023 Jul;
14(15):2727-2742.
PMID: 37474114
Serotonergic psychedelics are described to have activation of the serotonin 2A receptor (5-HT) as their main pharmacological action. Despite their relevance, the molecular mechanisms underlying the psychedelic effects induced by...
5.
Challenges for chemistry in Ukraine after the war: Ukrainian science requires rebuilding and support
Kondratov I, Moroz Y, Gorgulla C, Grygorenko O, Komarov I, Wagner G, et al.
Proc Natl Acad Sci U S A
. 2022 Dec;
119(50):e2210686119.
PMID: 36472958
The unprovoked Russian invasion has created considerable challenges for Ukrainian science. In this article, we discuss actions needed to support and rebuild Ukrainian science and educational systems. The proposed actions...
6.
Poulie C, Pottie E, Simon I, Harpsoe K, DAndrea L, Komarov I, et al.
J Med Chem
. 2022 Sep;
65(18):12031-12043.
PMID: 36099411
The serotonin 2A receptor (5-HTR) is the mediator of the psychedelic effects of serotonergic psychedelics, which have shown promising results in clinical studies for several neuropsychiatric indications. The 5-HTR is...
7.
Meng B, Grage S, Babii O, Takamiya M, MacKinnon N, Schober T, et al.
Small
. 2022 Sep;
18(41):e2107308.
PMID: 36074982
A labeling strategy for in vivo F-MRI (magnetic resonance imaging) based on highly fluorinated, short hydrophilic peptide probes, is developed. As dual-purpose probes, they are functionalized further by a fluorophore...
8.
Komarov I, Tolstanova G, Kuznietsova H, Dziubenko N, Yanchuk P, Shtanova L, et al.
J Photochem Photobiol B
. 2022 Jun;
233:112479.
PMID: 35660309
An in vivo study of a photoswitchable cytotoxic peptide LMB040 has been undertaken on a chemically induced hepatocellular carcinoma model in immunocompetent rats. We analysed the pharmacokinetic profile of the...
9.
Chernykh A, Chernykh A, Radchenko D, Chheda P, Rusanov E, Grygorenko O, et al.
Org Biomol Chem
. 2022 Mar;
20(15):3183-3200.
PMID: 35348173
A practical divergent synthetic approach is reported for the library of regio- and stereoisomers of glutamic acid analogs built on the spiro[3.3]heptane scaffold. Formation of the spirocyclic scaffold was achieved...
10.
Chalyk B, Khutorianskyi A, Vashchenko B, Danyleiko K, Grynyova A, Osipova A, et al.
J Org Chem
. 2021 Nov;
87(2):1001-1018.
PMID: 34843235
An efficient synthesis (up to a 200 g scale) of 3-hydroxypyrrolidin-2-ones bearing alkyl substituents or functional groups at the C-5 position is described. The reaction sequence started from 1,3-dipolar cycloaddition...