Anthony J Kirby
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Explore the profile of Anthony J Kirby including associated specialties, affiliations and a list of published articles.
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32
Citations
167
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Recent Articles
1.
Costa P, de Abreu R, Fontana A, Fiedler H, Kirby A, Quina F, et al.
J Colloid Interface Sci
. 2021 Jan;
588:456-468.
PMID: 33429342
Enzymes are highly significant catalysts, essential to biological systems, and a source of inspiration for the design of artificial enzymes. Although many models have been developed describing enzymatic catalysis, a...
2.
Komarov I, Yu Ishchenko A, Hovtvianitsa A, Stepanenko V, Kharchenko S, Bond A, et al.
Molecules
. 2019 Feb;
24(3).
PMID: 30764512
Unconstrained amides that undergo fast hydrolysis under mild conditions are valuable sources of information about how amide bonds may be activated in enzymatic transformations. We report a compound possessing an...
3.
Kirby A, Komarov I, Wothers P, Feeder N
Angew Chem Int Ed Engl
. 2018 May;
37(6):785-786.
PMID: 29711382
The title amide 1 behaves more like a ketone-up to a point! The crystal structure of this (90°) twisted amide shows a pyramidal nitrogen atom next to a planar carbonyl...
4.
Kirby A, Nome F
Acc Chem Res
. 2015 Jun;
48(7):1806-14.
PMID: 26075464
Historically, the chemistry of phosphate transfer-a class of reactions fundamental to the chemistry of Life-has been discussed almost exclusively in terms of the nucleophile and the leaving group. Reactivity always...
5.
Komarov I, Yanik S, Yu Ishchenko A, Davies J, Goodman J, Kirby A
J Am Chem Soc
. 2014 Dec;
137(2):926-30.
PMID: 25533746
1-Azatricyclo[3.3.1.1(3,7)]decan-2-one (3), the parent compound of a rare class of 90°-twisted amides, has finally been synthesized, using an unprecedented transformation. These compounds are of special interest as transition-state mimics for...
6.
Medeiros M, Wanderlind E, Mora J, Moreira R, Kirby A, Nome F
Org Biomol Chem
. 2013 Aug;
11(37):6272-84.
PMID: 23900489
Hydroxylamine reacts as an oxygen nucleophile, most likely via its ammonia oxide tautomer, towards both phosphate di- and triesters of 2-hydroxypyridine. But the reactions are very different. The product of...
7.
Kirby A, Medeiros M, Mora J, Oliveira P, Amer A, Williams N, et al.
J Org Chem
. 2013 Feb;
78(4):1343-53.
PMID: 23373989
Notwithstanding its half-life of 70 years at 25 °C, the spontaneous hydrolysis of the anion of di-2-pyridyl phosphate (DPP) is thousands of times faster (ca. 3000 at 100 °C, over...
8.
Medeiros M, Orth E, Manfredi A, Pavez P, Micke G, Kirby A, et al.
J Org Chem
. 2012 Nov;
77(23):10907-13.
PMID: 23167539
This work presents a detailed kinetic and mechanistic study of biologically interesting dephosphorylation reactions involving the exceptionally reactive nucleophilic group, hydroxamate. We compare results for hydroxamate groups anchored on the...
9.
Theoretical study of the importance of the spectator groups on the hydrolysis of phosphate triesters
Mora J, Kirby A, Nome F
J Org Chem
. 2012 Jul;
77(16):7061-70.
PMID: 22835036
The spontaneous hydrolysis of a series of five triaryl and two dialkyl aryl phosphate triesters, previously studied experimentally, is examined theoretically using two different hybrid density functional methods, B3LYP and...
10.
Babtie A, Lima M, Kirby A, Hollfelder F
Org Biomol Chem
. 2012 Jul;
10(40):8095-101.
PMID: 22832951
The hydrolytic reactions of sulfonate esters have previously been considered to occur by concerted mechanisms. We now report the observation of a break in a Brønsted correlation for the alkaline...