Igor Shats
Overview
Explore the profile of Igor Shats including associated specialties, affiliations and a list of published articles.
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27
Citations
941
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Recent Articles
1.
Li W, Nakano H, Fan W, Li Y, Sil P, Nakano K, et al.
JCI Insight
. 2023 Aug;
8(17).
PMID: 37581941
DNASE1L3, an enzyme highly expressed in DCs, is functionally important for regulating autoimmune responses to self-DNA and chromatin. Deficiency of DNASE1L3 leads to development of autoimmune diseases in both humans...
2.
Ji M, Xu X, Xu Q, Hsiao Y, Martin C, Ukraintseva S, et al.
Nat Metab
. 2023 Aug;
5(9):1526-1543.
PMID: 37537369
Restriction of methionine (MR), a sulfur-containing essential amino acid, has been reported to repress cancer growth and improve therapeutic responses in several preclinical settings. However, how MR impacts cancer progression...
3.
Li Y, Umbach D, Krahn J, Shats I, Li X, Li L
BMC Genomics
. 2021 Apr;
22(1):272.
PMID: 33858332
Background: Human cancer cell line profiling and drug sensitivity studies provide valuable information about the therapeutic potential of drugs and their possible mechanisms of action. The goal of those studies...
4.
Shats I, Li X
Aging (Albany NY)
. 2020 Dec;
12(23):23425-23426.
PMID: 33318311
No abstract available.
5.
Xu Q, Li Y, Gao X, Kang K, Williams J, Tong L, et al.
Nat Commun
. 2020 Aug;
11(1):3978.
PMID: 32770044
Methionine restriction, a dietary regimen that protects against metabolic diseases and aging, represses cancer growth and improves cancer therapy. However, the response of different cancer cells to this nutritional manipulation...
6.
Shats I, Williams J, Liu J, Makarov M, Wu X, Lih F, et al.
Cell Metab
. 2020 Mar;
31(3):564-579.e7.
PMID: 32130883
Nicotinamide adenine dinucleotide (NAD), a cofactor for hundreds of metabolic reactions in all cell types, plays an essential role in metabolism, DNA repair, and aging. However, how NAD metabolism is...
7.
Kang K, Meng Q, Shats I, Umbach D, Li M, Li Y, et al.
PLoS Comput Biol
. 2019 Dec;
15(12):e1007510.
PMID: 31790389
Quantifying cell-type proportions and their corresponding gene expression profiles in tissue samples would enhance understanding of the contributions of individual cell types to the physiological states of the tissue. Current...
8.
Li Y, Li M, Shats I, Krahn J, Flake G, Umbach D, et al.
PLoS One
. 2019 Jun;
14(6):e0218067.
PMID: 31199813
Due to the poor prognosis of advanced metastatic melanoma, it is crucial to find early biomarkers that help identify which melanomas will metastasize. By comparing the gene expression data from...
9.
Shats I, Deng M, Davidovich A, Zhang C, Kwon J, Manandhar D, et al.
Cell Death Differ
. 2017 Feb;
24(4):626-637.
PMID: 28211871
The Rb/E2F network has a critical role in regulating cell cycle progression and cell fate decisions. It is dysfunctional in virtually all human cancers, because of genetic lesions that cause...
10.
Shatz M, Shats I, Menendez D, Resnick M
Oncotarget
. 2015 Jul;
6(19):16963-80.
PMID: 26220208
The p53 tumor suppressor regulates transcription of genes associated with diverse cellular functions including apoptosis, growth arrest, DNA repair and differentiation. Recently, we established that p53 can modulate expression of...