Igor Rupniewski
Overview
Explore the profile of Igor Rupniewski including associated specialties, affiliations and a list of published articles.
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7
Citations
1275
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Recent Articles
1.
Rupniewski I, Rabuka D
Methods Mol Biol
. 2019 Jun;
2012:63-81.
PMID: 31161504
Use of the formylglycine generating enzyme (FGE)-a copper-dependent posttranslational protein modifier-represents a particularly elegant method taken directly from nature of introducing a unique amino acid into the larger context of...
2.
Bauzon M, Drake P, Barfield R, Cornali B, Rupniewski I, Rabuka D
Oncoimmunology
. 2019 Mar;
8(4):e1565859.
PMID: 30906660
Oncology treatment has been revolutionized by the introduction of immune checkpoint inhibitor drugs, which enable 20-40% of patients to generate anti-tumor immune responses. Combination treatment approaches with chemotherapeutic drugs may...
3.
Huang B, Kim Y, Banas S, Barfield R, Drake P, Rupniewski I, et al.
MAbs
. 2018 Sep;
10(8):1182-1189.
PMID: 30252630
The advantages of site-specific over stochastic bioconjugation technologies include homogeneity of product, minimal perturbation of protein structure/function, and - increasingly - the ability to perform structure activity relationship studies at...
4.
DeKelver R, Choi V, Moehle E, Paschon D, Hockemeyer D, Meijsing S, et al.
Genome Res
. 2010 May;
20(8):1133-42.
PMID: 20508142
Isogenic settings are routine in model organisms, yet remain elusive for genetic experiments on human cells. We describe the use of designed zinc finger nucleases (ZFNs) for efficient transgenesis without...
5.
Lee Y, Wilson R, Rupniewski I, Goodin D
Biochemistry
. 2010 Mar;
49(16):3412-9.
PMID: 20297780
P450cam from Pseudomonas putida is the best characterized member of the vast family of cytochrome P450s, and it has long been believed to have a more rigid and closed active...
6.
Perez E, Wang J, Miller J, Jouvenot Y, Kim K, Liu O, et al.
Nat Biotechnol
. 2008 Jul;
26(7):808-16.
PMID: 18587387
Homozygosity for the naturally occurring Delta32 deletion in the HIV co-receptor CCR5 confers resistance to HIV-1 infection. We generated an HIV-resistant genotype de novo using engineered zinc-finger nucleases (ZFNs) to...
7.
Miller J, Holmes M, Wang J, Guschin D, Lee Y, Rupniewski I, et al.
Nat Biotechnol
. 2007 Jul;
25(7):778-85.
PMID: 17603475
Genome editing driven by zinc-finger nucleases (ZFNs) yields high gene-modification efficiencies (>10%) by introducing a recombinogenic double-strand break into the targeted gene. The cleavage event is induced using two custom-designed...