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Adam J Waite

Explore the profile of Adam J Waite including associated specialties, affiliations and a list of published articles. Areas
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Articles 5
Citations 1387
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Recent Articles
1.
Hart S, Skelding D, Waite A, Burton J, Shou W
Quant Biol . 2019 Oct; 7(1):69-81. PMID: 31598381
Background: Microbes live in dynamic environments where nutrient concentrations fluctuate. Quantifying fitness in terms of birth rate and death rate in a wide range of environments is critical for understanding...
2.
Paschon D, Lussier S, Wangzor T, Xia D, Li P, Hinkley S, et al.
Nat Commun . 2019 Mar; 10(1):1133. PMID: 30850604
Genome editing for therapeutic applications often requires cleavage within a narrow sequence window. Here, to enable such high-precision targeting with zinc-finger nucleases (ZFNs), we have developed an expanded set of...
3.
Guschin D, Waite A, Katibah G, Miller J, Holmes M, Rebar E
Methods Mol Biol . 2010 Aug; 649:247-56. PMID: 20680839
The development of zinc finger nucleases for targeted gene modification can benefit from rapid functional assays that directly quantify activity at the endogenous target. Here we describe a simple procedure...
4.
Perez E, Wang J, Miller J, Jouvenot Y, Kim K, Liu O, et al.
Nat Biotechnol . 2008 Jul; 26(7):808-16. PMID: 18587387
Homozygosity for the naturally occurring Delta32 deletion in the HIV co-receptor CCR5 confers resistance to HIV-1 infection. We generated an HIV-resistant genotype de novo using engineered zinc-finger nucleases (ZFNs) to...
5.
Miller J, Holmes M, Wang J, Guschin D, Lee Y, Rupniewski I, et al.
Nat Biotechnol . 2007 Jul; 25(7):778-85. PMID: 17603475
Genome editing driven by zinc-finger nucleases (ZFNs) yields high gene-modification efficiencies (>10%) by introducing a recombinogenic double-strand break into the targeted gene. The cleavage event is induced using two custom-designed...