Igor A Schepetkin
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Explore the profile of Igor A Schepetkin including associated specialties, affiliations and a list of published articles.
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114
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1667
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Recent Articles
1.
Xu Q, Authi K, Kirpotina L, Schepetkin I, Quinn M, Cilibrizzi A
RSC Med Chem
. 2025 Jan;
PMID: 39886349
-Formyl peptide receptors (FPRs) are membrane receptors that are abundantly expressed in innate immune cells, including neutrophils and platelets, demonstrating potential new targets for immune system regulation and the treatment...
2.
Schepetkin I, Fischer A
Plants (Basel)
. 2024 Nov;
13(21).
PMID: 39519927
Leaf senescence is a developmental process allowing nutrient remobilization to sink organs. Previously cysteine proteases have been found to be highly expressed during leaf senescence in different plant species. Using...
3.
Andrianov V, Schepetkin I, Bazan L, Gainutdinov K, Kovrizhina A, Atochin D, et al.
Molecules
. 2024 Aug;
29(16).
PMID: 39202899
IQ-1 (11-indeno[1,2-]quinoxalin-11-one oxime) is a specific c-Jun N-terminal kinase (JNK) inhibitor with anticancer and neuro- and cardioprotective properties. Because aryloxime derivatives undergo cytochrome P450-catalyzed oxidation to nitric oxide (NO) and...
4.
Schepetkin I, Ozek G, Ozek T, Kirpotina L, Khlebnikov A, Aycicek K, et al.
Plants (Basel)
. 2024 Aug;
13(15).
PMID: 39124181
(Pall. ex Pursh) G.L. Nesom & G.I. Baird) is used in traditional medicine to treat various diseases; however, little is known about the immunomodulatory activity of essential oil from this...
5.
Crocetti L, Khlebnikov A, Guerrini G, Schepetkin I, Melani F, Giovannoni M, et al.
Molecules
. 2024 Jun;
29(11).
PMID: 38893295
Chronic inflammation contributes to a number of diseases. Therefore, control of the inflammatory response is an important therapeutic goal. To identify novel anti-inflammatory compounds, we synthesized and screened a library...
6.
Crocetti L, Catarzi F, Giovannoni M, Vergelli C, Bartolucci G, Pallecchi M, et al.
RSC Med Chem
. 2024 Apr;
15(4):1247-1257.
PMID: 38665832
Human neutrophil elastase (HNE) plays an essential role in host defense against bacteria but is also involved in several respiratory diseases. Recent reports suggest that compounds exhibiting a combination of...
7.
Dosoky N, Kirpotina L, Schepetkin I, Khlebnikov A, Lisonbee B, Black J, et al.
Molecules
. 2023 Nov;
28(21).
PMID: 37959750
(L.) Moench is a medicinal plant commonly used for the treatment of upper respiratory tract infections, the common cold, sore throat, migraine, colic, stomach cramps, and toothaches and the promotion...
8.
Francavilla F, Sarcina F, Schepetkin I, Kirpotina L, Contino M, Schirizzi A, et al.
Eur J Med Chem
. 2023 Oct;
261:115854.
PMID: 37839346
Formyl peptide receptor-1 (FPR1) is a G protein-coupled chemoattractant receptor that plays a crucial role in the trafficking of leukocytes into the sites of bacterial infection and inflammation. Recently, FPR1...
9.
Schepetkin I, Danilets M, Ligacheva A, Trofimova E, Selivanova N, Sherstoboev E, et al.
Molecules
. 2023 Sep;
28(18).
PMID: 37764432
The genus has been used in the preparation of therapies for a number of medical problems, yet not much is known about the therapeutic high-molecular-weight compounds present in extracts from...
10.
Plotnikov M, Chernysheva G, Smolyakova V, Aliev O, Anishchenko A, Ulyakhina O, et al.
Pharmaceuticals (Basel)
. 2023 Aug;
16(8).
PMID: 37630972
The activation of -Jun N-terminal kinase (JNK) plays an important role in stroke outcomes. Tryptanthrin-6-oxime (TRYP-Ox) is reported to have high affinity for JNK and anti-inflammatory activity and may be...