Ignas Masilionis
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Explore the profile of Ignas Masilionis including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
956
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Recent Articles
11.
Burdziak C, Alonso-Curbelo D, Walle T, Reyes J, Barriga F, Haviv D, et al.
Science
. 2023 May;
380(6645):eadd5327.
PMID: 37167403
The response to tumor-initiating inflammatory and genetic insults can vary among morphologically indistinguishable cells, suggesting as yet uncharacterized roles for epigenetic plasticity during early neoplasia. To investigate the origins and...
12.
Persad S, Choo Z, Dien C, Sohail N, Masilionis I, Chaligne R, et al.
Nat Biotechnol
. 2023 Mar;
41(12):1746-1757.
PMID: 36973557
Metacells are cell groupings derived from single-cell sequencing data that represent highly granular, distinct cell states. Here we present single-cell aggregation of cell states (SEACells), an algorithm for identifying metacells...
13.
Zhang H, Karnoub E, Umeda S, Chaligne R, Masilionis I, McIntyre C, et al.
Nat Commun
. 2023 Feb;
14(1):749.
PMID: 36765116
Despite insights gained by bulk DNA sequencing of cancer it remains challenging to resolve the admixture of normal and tumor cells, and/or of distinct tumor subclones; high-throughput single-cell DNA sequencing...
14.
Quintanal-Villalonga A, Chan J, Masilionis I, Gao V, Xie Y, Allaj V, et al.
STAR Protoc
. 2022 Oct;
3(4):101776.
PMID: 36313536
We report a protocol for obtaining high-quality single-cell transcriptomics data from human lung biospecimens acquired from core needle biopsies, fine-needle aspirates, surgical resection, and pleural effusions. The protocol relies upon...
15.
Chan J, Zaidi S, Love J, Zhao J, Setty M, Wadosky K, et al.
Science
. 2022 Aug;
377(6611):1180-1191.
PMID: 35981096
Drug resistance in cancer is often linked to changes in tumor cell state or lineage, but the molecular mechanisms driving this plasticity remain unclear. Using murine organoid and genetically engineered...
16.
Andrlova H, Miltiadous O, Kousa A, Dai A, DeWolf S, Violante S, et al.
Sci Transl Med
. 2022 May;
14(646):eabj2829.
PMID: 35613281
Microbial diversity is associated with improved outcomes in recipients of allogeneic hematopoietic cell transplantation (allo-HCT), but the mechanism underlying this observation is unclear. In a cohort of 174 patients who...
17.
Ganesh K, Basnet H, Kaygusuz Y, Laughney A, He L, Sharma R, et al.
Nat Cancer
. 2022 Feb;
1(11):1128.
PMID: 35122071
No abstract available.
18.
Chan J, Quintanal-Villalonga A, Gao V, Xie Y, Allaj V, Chaudhary O, et al.
Cancer Cell
. 2021 Oct;
39(11):1479-1496.e18.
PMID: 34653364
Small cell lung cancer (SCLC) is an aggressive malignancy that includes subtypes defined by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A, -N, and -P, respectively). To define the heterogeneity...
19.
Bakhoum M, Francis J, Agustinus A, Earlie E, Di Bona M, Abramson D, et al.
Nat Commun
. 2021 Sep;
12(1):5402.
PMID: 34518527
Chromosomal instability (CIN) and epigenetic alterations have been implicated in tumor progression and metastasis; yet how these two hallmarks of cancer are related remains poorly understood. By integrating genetic, epigenetic,...
20.
Wang R, Sharma R, Shen X, Laughney A, Funato K, Clark P, et al.
Stem Cell Reports
. 2020 Jul;
15(1):275-277.
PMID: 32668221
No abstract available.