Ignacio Del Valle
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Explore the profile of Ignacio Del Valle including associated specialties, affiliations and a list of published articles.
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Citations
957
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Recent Articles
11.
Suntharalingham J, Ishida M, Buonocore F, Del Valle I, Solanky N, Demetriou C, et al.
F1000Res
. 2020 May;
8:90.
PMID: 31497289
Cyclin-dependent kinase inhibitor 1C (CDKN1C) is a key negative regulator of cell growth encoded by a paternally imprinted/maternally expressed gene in humans. Loss-of-function variants in are associated with an overgrowth...
12.
Buonocore F, Clifford-Mobley O, King T, Striglioni N, Man E, Suntharalingham J, et al.
J Endocr Soc
. 2019 Nov;
3(12):2341-2360.
PMID: 31745530
Context: The genetic basis of human sex development is slowly being elucidated, and >40 different genetic causes of differences (or disorders) of sex development (DSDs) have now been reported. However,...
13.
Del Valle I, Buonocore F, Duncan A, Lin L, Barenco M, Parnaik R, et al.
Wellcome Open Res
. 2017 May;
2:25.
PMID: 28459107
Background: In humans, the adrenal glands and gonads undergo distinct biological events between 6-10 weeks post conception (wpc), such as testis determination, the onset of steroidogenesis and primordial germ cell...
14.
Buonocore F, Kuhnen P, Suntharalingham J, Del Valle I, Digweed M, Stachelscheid H, et al.
J Clin Invest
. 2017 Mar;
127(5):1700-1713.
PMID: 28346228
It is well established that somatic genomic changes can influence phenotypes in cancer, but the role of adaptive changes in developmental disorders is less well understood. Here we have used...
15.
Blakeley P, Fogarty N, Del Valle I, Wamaitha S, Hu T, Elder K, et al.
Development
. 2015 Oct;
142(20):3613.
PMID: 26487783
There were errors published in Development 142, 3151-3165.In the issue published online on 22 September 2015, Fig. 3 was mislabelled: panels A, B, C and D should have been B,...
16.
Blakeley P, Fogarty N, Del Valle I, Wamaitha S, Hu T, Elder K, et al.
Development
. 2015 Aug;
142(18):3151-65.
PMID: 26293300
Here, we provide fundamental insights into early human development by single-cell RNA-sequencing of human and mouse preimplantation embryos. We elucidate conserved transcriptional programs along with those that are human specific....
17.
Wamaitha S, Del Valle I, Cho L, Wei Y, Fogarty N, Blakeley P, et al.
Genes Dev
. 2015 Jun;
29(12):1239-55.
PMID: 26109048
Transcription factor-mediated reprograming is a powerful method to study cell fate changes. In this study, we demonstrate that the transcription factor Gata6 can initiate reprograming of multiple cell types to...
18.
Del Valle I, Rudloff S, Carles A, Li Y, Liszewska E, Vogt R, et al.
Development
. 2013 Mar;
140(8):1684-92.
PMID: 23487312
The leukemia inhibitory factor (Lif) signaling pathway is a crucial determinant for mouse embryonic stem (mES) cell self-renewal and pluripotency. One of the hallmarks of mES cells, their compact growth...
19.
Hoffmeyer K, Raggioli A, Rudloff S, Anton R, Hierholzer A, Del Valle I, et al.
Science
. 2012 Jun;
336(6088):1549-54.
PMID: 22723415
Telomerase activity controls telomere length and plays a pivotal role in stem cells, aging, and cancer. Here, we report a molecular link between Wnt/β-catenin signaling and the expression of the...
20.
Elvira G, Moreno B, Del Valle I, Garcia-Sanz J, Canillas M, Chinarro E, et al.
J Biomater Appl
. 2011 May;
26(8):1069-89.
PMID: 21586599
Aiming to characterize the use of biomaterials in cancer therapy, we took advantage of the n-type semiconductor properties, which upon irradiation excite their electrons into the conduction band to induce...