Ignacio A Rodriguez-Brenes
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Explore the profile of Ignacio A Rodriguez-Brenes including associated specialties, affiliations and a list of published articles.
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14
Citations
202
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Recent Articles
1.
Rodriguez-Brenes I, Wodarz D, Komarova N
Phys Rev E
. 2020 Apr;
101(3-1):032404.
PMID: 32289892
The process of range expansion (colonization) is one of the basic types of biological dynamics, whereby a species grows and spreads outwards, occupying new territories. Spatial modeling of this process...
2.
Rodriguez-Brenes I, Komarova N, Wodarz D
J Theor Biol
. 2018 Oct;
460:144-152.
PMID: 30315815
Genome instability is a characteristic of most cancers, contributing to the acquisition of genetic alterations that drive tumor progression. One important source of genome instability is linked to telomere dysfunction...
3.
Rodriguez-Brenes I, Kurtova A, Lin C, Lee Y, Xiao J, Mims M, et al.
Cancer Res
. 2017 Feb;
77(9):2231-2241.
PMID: 28235762
Chemotherapy has been shown to enrich cancer stem cells in tumors. Recently, we demonstrated that administration of chemotherapy to human bladder cancer xenografts could trigger a wound-healing response that mobilizes...
4.
Rodriguez-Brenes I, Hofacre A, Fan H, Wodarz D
PLoS Comput Biol
. 2017 Jan;
13(1):e1005241.
PMID: 28107341
While virus growth dynamics have been well-characterized in several infections, data are typically collected once the virus population becomes easily detectable. Earlier dynamics, however, remain less understood. We recently reported...
5.
Rodriguez-Brenes I, Wodarz D
Elife
. 2016 Jan;
5:e12481.
PMID: 26807592
Measuring the length distribution of telomeres can reveal information about biological processes that are otherwise difficult to analyze experimentally.
6.
Rodriguez-Brenes I, Wodarz D, Komarova N
Sci Rep
. 2015 Dec;
5:17660.
PMID: 26647820
To study quantitatively replicative senescence as a tumor suppressor mechanism, we investigate the distribution of a growing clonal cell population restricted by Hayflick's limit. We find that in the biologically...
7.
Rodriguez-Brenes I, Wodarz D, Komarova N
Math Biosci
. 2015 Sep;
270(Pt A):135-41.
PMID: 26344137
Healthy human tissue is highly regulated to maintain homeostasis. Secreted negative feedback factors that inhibit stem cell division and stem cell self-renewal play a fundamental role in establishing this control....
8.
Rodriguez-Brenes I, Wodarz D
Proc Natl Acad Sci U S A
. 2015 Jul;
112(29):8843-50.
PMID: 26195751
Clonal evolutionary processes can drive pathogenesis in human diseases, with cancer being a prominent example. To prevent or treat cancer, mechanisms that can potentially interfere with clonal evolutionary processes need...
9.
Rodriguez-Brenes I, Komarova N, Wodarz D
Cancer Res
. 2014 Jan;
74(6):1661-9.
PMID: 24453004
Mutations associated with hematopoietic malignancies have been repeatedly identified in healthy individuals. For certain cases, such as the t(14;18) translocation and monoclonal B-cell lymphocytosis, no clear link between the presence...
10.
Rodriguez-Brenes I, Wodarz D, Komarova N
J R Soc Interface
. 2013 Jul;
10(86):20130410.
PMID: 23825115
Normal somatic cells are capable of only a limited number of divisions, which prevents unlimited cell proliferation and the onset of tumours. Cancer cells find ways to circumvent this obstacle,...