Andrew Hofacre
Overview
Explore the profile of Andrew Hofacre including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
10
Citations
157
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Mitchell L, Yagiz K, Hofacre A, Viaud S, Munday A, Espinoza F, et al.
Oncotarget
. 2019 May;
10(23):2252-2269.
PMID: 31040917
Immune checkpoint inhibitors (CPIs) are associated with a number of immune-related adverse events and low response rates. We provide preclinical evidence for use of a retroviral replicating vector (RRV) selective...
2.
Hofacre A, Yagiz K, Mendoza D, Espinoza F, Munday A, Burrascano C, et al.
Hum Gene Ther
. 2017 Dec;
29(4):437-451.
PMID: 29216761
Toca 511, a retroviral replicating vector (RRV), uses an internal ribosomal entry site (IRES) to express an optimized yeast cytosine deaminase (yCD2), which converts 5-fluorocytosine to 5-fluorouracil. This configuration is...
3.
Lin A, Twitty C, Burnett R, Hofacre A, Mitchell L, Espinoza F, et al.
Mol Ther Nucleic Acids
. 2017 Mar;
6:221-232.
PMID: 28325288
Tumor cells express a number of immunosuppressive molecules that can suppress anti-tumor immune responses. Efficient delivery of small interfering RNAs to treat a wide range of diseases including cancers remains...
4.
Rodriguez-Brenes I, Hofacre A, Fan H, Wodarz D
PLoS Comput Biol
. 2017 Jan;
13(1):e1005241.
PMID: 28107341
While virus growth dynamics have been well-characterized in several infections, data are typically collected once the virus population becomes easily detectable. Earlier dynamics, however, remain less understood. We recently reported...
5.
Wodarz D, Hofacre A, Lau J, Sun Z, Fan H, Komarova N
PLoS Comput Biol
. 2012 Jun;
8(6):e1002547.
PMID: 22719239
Oncolytic viruses replicate selectively in tumor cells and can serve as targeted treatment agents. While promising results have been observed in clinical trials, consistent success of therapy remains elusive. The...
6.
Hofacre A, Wodarz D, Komarova N, Fan H
Virology
. 2011 Dec;
423(1):89-96.
PMID: 22192628
Conditionally-replicating adenoviruses (CRAds) and other oncolytic viruses replicate selectively in tumor cells, presenting a potential cancer treatment approach. To optimize application of these viruses, understanding of early spread of these...
7.
Hofacre A, Fan H
Viruses
. 2011 Oct;
2(12):2618-48.
PMID: 21994634
Jaagsiekte sheep retrovirus (JSRV) is the causative agent of a lung cancer in sheep known as ovine pulmonary adenocarcinoma (OPA). The disease has been identified around the world in several...
8.
Nitta T, Hofacre A, Hull S, Fan H
J Virol
. 2009 Sep;
83(23):12499-511.
PMID: 19776134
Jaagsiekte sheep retrovirus (JSRV) is a simple betaretrovirus causing a contagious lung cancer of sheep. JSRV encodes unspliced and spliced viral RNAs, among which unspliced RNA encodes Gag and Pol...
9.
Hofacre A, Nitta T, Fan H
J Virol
. 2009 Sep;
83(23):12483-98.
PMID: 19776124
Retroviruses express Gag and Pol proteins by translation of unspliced genome-length viral RNA. For some retroviruses, transport of unspliced viral RNA to the cytoplasm is mediated by small regulatory proteins...
10.
Hofacre A, Fan H
J Virol
. 2004 Sep;
78(19):10479-89.
PMID: 15367614
Jaagsiekte sheep retrovirus (JSRV) is an exogenous retrovirus of sheep that induces a contagious lung cancer, ovine pulmonary adenocarcinoma. We previously showed that the gene encoding JSRV envelope protein (Env)...