Ian W Glaaser
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Explore the profile of Ian W Glaaser including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
386
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Recent Articles
1.
Nguyen H, Glaaser I, Slesinger P
Front Physiol
. 2024 Jun;
15:1386645.
PMID: 38903913
Ion channels play a pivotal role in regulating cellular excitability and signal transduction processes. Among the various ion channels, G-protein-coupled inwardly rectifying potassium (GIRK) channels serve as key mediators of...
2.
Mathiharan Y, Glaaser I, Zhao Y, Robertson M, Skiniotis G, Slesinger P
Cell Rep
. 2021 Aug;
36(8):109619.
PMID: 34433062
G-protein-gated inwardly rectifying potassium (GIRK) channels are important for determining neuronal excitability. In addition to G proteins, GIRK channels are potentiated by membrane cholesterol, which is elevated in the brains...
3.
Zhao Y, Gameiro-Ros I, Glaaser I, Slesinger P
Trends Pharmacol Sci
. 2021 Jan;
42(3):203-215.
PMID: 33468322
G protein-gated inwardly rectifying potassium (GIRK) channels are essential regulators of cell excitability in the brain. While they are implicated in a variety of neurological diseases in both human and...
4.
Zhao Y, Ung P, Zahoranszky-Kohalmi G, Zakharov A, Martinez N, Simeonov A, et al.
Cell Rep
. 2020 Jun;
31(11):107770.
PMID: 32553165
G-protein-gated inwardly rectifying K (GIRK) channels are essential effectors of inhibitory neurotransmission in the brain. GIRK channels have been implicated in diseases with abnormal neuronal excitability, including epilepsy and addiction....
5.
Lacin E, Aryal P, Glaaser I, Bodhinathan K, Tsai E, Marsh N, et al.
J Gen Physiol
. 2017 Jul;
149(8):799-811.
PMID: 28720589
G protein-gated inwardly rectifying potassium (GIRK) channels control neuronal excitability in the brain and are implicated in several different neurological diseases. The anionic phospholipid phosphatidylinositol 4,5 bisphosphate (PIP) is an...
6.
Glaaser I, Slesinger P
Sci Rep
. 2017 Jul;
7(1):4592.
PMID: 28676630
Activation of G protein-gated inwardly rectifying potassium (GIRK) channels leads to a hyperpolarization of the neuron's membrane potential, providing an important component of inhibition in the brain. In addition to...
7.
Glaaser I, Slesinger P
Int Rev Neurobiol
. 2015 Oct;
123:117-60.
PMID: 26422984
G protein-gated inwardly rectifying potassium (GIRK; Kir3) channels, which are members of the large family of inwardly rectifying potassium channels (Kir1-Kir7), regulate excitability in the heart and brain. GIRK channels...
8.
Glaaser I, Osteen J, Puckerin A, Sampson K, Jin X, Kass R
Nat Commun
. 2012 Mar;
3:706.
PMID: 22426227
The cardiac voltage-gated sodium channel (Na(V)1.5) underlies impulse conduction in the heart, and its depolarization-induced inactivation is essential in control of the duration of the QT interval of the electrocardiogram....
9.
Bankston J, Sampson K, Kateriya S, Glaaser I, Malito D, Chung W, et al.
Channels (Austin)
. 2008 Aug;
1(4):273-80.
PMID: 18708744
Inherited mutations of SCN5A, the gene that encodes Na(V)1.5, the alpha subunit of the principle voltage-gated Na(+) channel in the heart, cause congenital Long QT Syndrome variant 3 (LQT-3) by...
10.
Holland K, Kearney J, Glauser T, Buck G, Keddache M, Blankston J, et al.
Neurosci Lett
. 2008 Feb;
433(1):65-70.
PMID: 18242854
Mutations in the sodium channel genes SCN1A and SCN2A have been identified in monogenic childhood epilepsies, but SCN3A has not previously been investigated as a candidate gene for epilepsy. We...