Ian W Folkert
Overview
Explore the profile of Ian W Folkert including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
287
Followers
0
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Recent Articles
1.
Folkert I, Molina Arocho W, To T, Devalaraja S, Molina I, Shoush J, et al.
J Exp Med
. 2024 Sep;
221(10).
PMID: 39347789
We define a subset of macrophages in the tumor microenvironment characterized by high intracellular iron and enrichment of heme and iron metabolism genes. These iron-rich tumor-associated macrophages (iTAMs) supported angiogenesis...
2.
Li N, Zhu Q, Tian Y, Ahn K, Wang X, Cramer Z, et al.
Nat Commun
. 2023 Nov;
14(1):7915.
PMID: 38036590
The initiation and progression of cancer are intricately linked to the tumor microenvironment (TME). Understanding the function of specific cancer-TME interactions poses a major challenge due in part to the...
3.
Dang M, Gonzalez M, Gaonkar K, Rathi K, Young P, Arif S, et al.
Cell Rep
. 2023 May;
42(6):112600.
PMID: 37235472
No abstract available.
4.
Maddipati R, Norgard R, Baslan T, Rathi K, Zhang A, Saeid A, et al.
Cancer Discov
. 2021 Sep;
12(2):542-561.
PMID: 34551968
The degree of metastatic disease varies widely among patients with cancer and affects clinical outcomes. However, the biological and functional differences that drive the extent of metastasis are poorly understood....
5.
Norgard R, Pitarresi J, Maddipati R, Aiello-Couzo N, Balli D, Li J, et al.
EMBO Rep
. 2021 Jul;
22(9):e51872.
PMID: 34324787
Epithelial plasticity, or epithelial-to-mesenchymal transition (EMT), is a well-recognized form of cellular plasticity, which endows tumor cells with invasive properties and alters their sensitivity to various agents, thus representing a...
6.
Dang M, Gonzalez M, Gaonkar K, Rathi K, Young P, Arif S, et al.
Cell Rep
. 2021 Mar;
34(13):108917.
PMID: 33789113
Tumor-associated macrophages (TAMs) play an important role in tumor immunity and comprise of subsets that have distinct phenotype, function, and ontology. Transcriptomic analyses of human medulloblastoma, the most common malignant...
7.
Alam Z, Devalaraja S, Li M, To T, Folkert I, Mitchell-Velasquez E, et al.
Cell Rep
. 2020 Jul;
31(13):107825.
PMID: 32610126
Activated macrophages must carefully calibrate their inflammatory responses to balance efficient pathogen control with inflammation-mediated tissue damage, but the molecular underpinnings of this "balancing act" remain unclear. Using genetically engineered...
8.
Devalaraja S, To T, Folkert I, Natesan R, Alam M, Li M, et al.
Cell
. 2020 Mar;
180(6):1098-1114.e16.
PMID: 32169218
The immunosuppressive tumor microenvironment (TME) is a major barrier to immunotherapy. Within solid tumors, why monocytes preferentially differentiate into immunosuppressive tumor-associated macrophages (TAMs) rather than immunostimulatory dendritic cells (DCs) remains...
9.
10.
Folkert I, Sinnamon A, Concors S, Bennett B, Fraker D, Mahmoud N, et al.
Ann Surg Oncol
. 2019 Nov;
27(3):855-863.
PMID: 31701298
Background: Small (< 2 cm) and diminutive (< 1 cm) rectal neuroendocrine tumors (RNETs) are often described as indolent lesions. A large single-center experience was reviewed to determine the incidence...