Ian S Millett
Overview
Explore the profile of Ian S Millett including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
1439
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Recent Articles
1.
Zagrovic B, Jayachandran G, Millett I, Doniach S, Pande V
J Mol Biol
. 2005 Sep;
353(2):232-41.
PMID: 16171817
Using synchrotron radiation and the small-angle X-ray scattering technique we have measured the radii of gyration of a series of alanine-based alpha-helix-forming peptides of the composition Ace-(AAKAA)(n)-GY-NH(2), n=2-7, in aqueous...
2.
Zagrovic B, Lipfert J, Sorin E, Millett I, van Gunsteren W, Doniach S, et al.
Proc Natl Acad Sci U S A
. 2005 Aug;
102(33):11698-703.
PMID: 16085707
Polyproline type II (PPII) helix has emerged recently as the dominant paradigm for describing the conformation of unfolded polypeptides. However, most experimental observables used to characterize unfolded proteins typically provide...
3.
Uversky V, Yamin G, Munishkina L, Karymov M, Millett I, Doniach S, et al.
Brain Res Mol Brain Res
. 2005 Mar;
134(1):84-102.
PMID: 15790533
Substantial evidence suggests that the aggregation of the presynaptic protein alpha-synuclein is a key step in the etiology of Parkinson's disease (PD). Although the molecular mechanisms underlying alpha-synuclein aggregation remain...
4.
Bai Y, Das R, Millett I, Herschlag D, Doniach S
Proc Natl Acad Sci U S A
. 2005 Jan;
102(4):1035-40.
PMID: 15647360
Understanding biological and physical processes involving nucleic acids, such as the binding of proteins to DNA and RNA, DNA condensation, and RNA folding, requires an understanding of the ion atmosphere...
5.
Kohn J, Millett I, Jacob J, Zagrovic B, Dillon T, Cingel N, et al.
Proc Natl Acad Sci U S A
. 2004 Aug;
101(34):12491-6.
PMID: 15314214
Spectroscopic studies have identified a number of proteins that appear to retain significant residual structure under even strongly denaturing conditions. Intrinsic viscosity, hydrodynamic radii, and small-angle x-ray scattering studies, in...
6.
Ahmad A, Millett I, Doniach S, Uversky V, Fink A
J Biol Chem
. 2004 Jan;
279(15):14999-5013.
PMID: 14736893
Fibrillar deposits of insulin cause serious problems in implantable insulin pumps, commercial production of insulin, and for some diabetics. We performed a systematic investigation of the effect of urea-induced structural...
7.
Permyakov S, Millett I, Doniach S, Permyakov E, Uversky V
Proteins
. 2003 Nov;
53(4):855-62.
PMID: 14635127
The structure of C-terminal domain (CaD136, C-terminal residues 636-771) of chicken gizzard caldesmon has been analyzed by a variety of physico-chemical methods. We are showing here that CaD136 does not...
8.
Ahmad A, Millett I, Doniach S, Uversky V, Fink A
Biochemistry
. 2003 Oct;
42(39):11404-16.
PMID: 14516191
Native zinc-bound insulin exists as a hexamer at neutral pH. Under destabilizing conditions, the hexamer dissociates, and is very prone to forming fibrils. Insulin fibrils exhibit the typical properties of...
9.
Das R, Kwok L, Millett I, Bai Y, Mills T, Jacob J, et al.
J Mol Biol
. 2003 Sep;
332(2):311-9.
PMID: 12948483
Large RNAs can collapse into compact conformations well before the stable formation of the tertiary contacts that define their final folds. This study identifies likely physical mechanisms driving these early...
10.
Goers J, Manning-Bog A, McCormack A, Millett I, Doniach S, Di Monte D, et al.
Biochemistry
. 2003 Jul;
42(28):8465-71.
PMID: 12859192
The aggregation of alpha-synuclein is believed to play an important role in the pathogenesis of Parkinson's disease as well as other neurodegenerative disorders ("synucleinopathies"). However, the function of alpha-synuclein under...