Daniel Herschlag
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Explore the profile of Daniel Herschlag including associated specialties, affiliations and a list of published articles.
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200
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8151
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Recent Articles
1.
Du S, Kretsch R, Parres-Gold J, Pieri E, Cruzeiro V, Zhu M, et al.
Science
. 2025 Feb;
387(6735):eado5068.
PMID: 39946472
Enzymes exist in ensembles of states that encode the energetics underlying their catalysis. Conformational ensembles built from 1231 structures of 17 serine proteases revealed atomic-level changes across their reaction states....
2.
Wightman F, Yang G, Martin des Taillades Y, LEsperance-Kerckhoff C, Grote S, Allan M, et al.
bioRxiv
. 2024 Oct;
PMID: 39386640
In recent years, RNA has been increasingly recognized for its essential roles in biology, functioning not only as a carrier of genetic information but also as a dynamic regulator of...
3.
Shin J, Cuevas L, Roy R, Bonilla S, Al-Hashimi H, Greenleaf W, et al.
RNA
. 2024 Oct;
30(12):1646-1659.
PMID: 39362695
Folded RNAs contain tertiary contact motifs whose structures and energetics are conserved across different RNAs. The transferable properties of RNA motifs simplify the RNA folding problem, but measuring energetic and...
4.
Du S, Wankowicz S, Yabukarski F, Doukov T, Herschlag D, Fraser J
Methods Enzymol
. 2023 Sep;
688:223-254.
PMID: 37748828
Conformational ensembles underlie all protein functions. Thus, acquiring atomic-level ensemble models that accurately represent conformational heterogeneity is vital to deepen our understanding of how proteins work. Modeling ensemble information from...
5.
Markin C, Mokhtari D, Du S, Doukov T, Sunden F, Cook J, et al.
Proc Natl Acad Sci U S A
. 2023 Jul;
120(29):e2219074120.
PMID: 37428919
Using high-throughput microfluidic enzyme kinetics (HT-MEK), we measured over 9,000 inhibition curves detailing impacts of 1,004 single-site mutations throughout the alkaline phosphatase PafA on binding affinity for two transition state...
6.
Ken M, Roy R, Geng A, Ganser L, Manghrani A, Cullen B, et al.
Nature
. 2023 Jun;
618(7967):E35.
PMID: 37296211
No abstract available.
7.
Du S, Wankowicz S, Yabukarski F, Doukov T, Herschlag D, Fraser J
bioRxiv
. 2023 May;
PMID: 37205593
Conformational ensembles underlie all protein functions. Thus, acquiring atomic-level ensemble models that accurately represent conformational heterogeneity is vital to deepen our understanding of how proteins work. Modeling ensemble information from...
8.
Ken M, Roy R, Geng A, Ganser L, Manghrani A, Cullen B, et al.
Nature
. 2023 May;
617(7962):835-841.
PMID: 37198487
Cellular processes are the product of interactions between biomolecules, which associate to form biologically active complexes. These interactions are mediated by intermolecular contacts, which if disrupted, lead to alterations in...
9.
Shin J, Bonilla S, Denny S, Greenleaf W, Herschlag D
Proc Natl Acad Sci U S A
. 2023 Mar;
120(11):e2220485120.
PMID: 36897989
Structured RNAs and RNA/protein complexes perform critical cellular functions. They often contain structurally conserved tertiary contact "motifs," whose occurrence simplifies the RNA folding landscape. Prior studies have focused on the...
10.
Doukov T, Herschlag D, Yabukarski F
Acta Crystallogr D Struct Biol
. 2023 Mar;
79(Pt 3):212-223.
PMID: 36876431
X-ray crystallography has been invaluable in delivering structural information about proteins. Previously, an approach has been developed that allows high-quality X-ray diffraction data to be obtained from protein crystals at...