Ian R Wickersham
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Explore the profile of Ian R Wickersham including associated specialties, affiliations and a list of published articles.
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48
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3350
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Recent Articles
1.
Lazaridis I, Crittenden J, Ahn G, Hirokane K, Wickersham I, Yoshida T, et al.
Curr Biol
. 2024 Oct;
34(22):5263-5283.e8.
PMID: 39447573
Balanced activity of canonical direct D1 and indirect D2 basal ganglia pathways is considered a core requirement for normal movement, and their imbalance is an etiologic factor in movement and...
2.
Lazaridis I, Crittenden J, Ahn G, Hirokane K, Yoshida T, Wickersham I, et al.
bioRxiv
. 2024 Jun;
PMID: 38915684
Balanced activity of canonical direct D1 and indirect D2 basal ganglia pathways is considered a core requirement for normal movement, and their imbalance is an etiologic factor in movement and...
3.
Jin L, Sullivan H, Zhu M, Lavin T, Matsuyama M, Fu X, et al.
Nat Neurosci
. 2024 Jan;
27(2):385.
PMID: 38267526
No abstract available.
4.
Jin L, Sullivan H, Zhu M, Lavin T, Matsuyama M, Fu X, et al.
Nat Neurosci
. 2024 Jan;
27(2):373-383.
PMID: 38212587
Rabies-virus-based monosynaptic tracing is a widely used technique for mapping neural circuitry, but its cytotoxicity has confined it primarily to anatomical applications. Here we present a second-generation system for labeling...
5.
Jin L, Sullivan H, Zhu M, Lea N, Lavin T, Fu X, et al.
Cell Rep Methods
. 2023 Nov;
3(11):100644.
PMID: 37989085
Rabies viral vectors have become important components of the systems neuroscience toolkit, allowing both direct retrograde targeting of projection neurons and monosynaptic tracing of inputs to defined postsynaptic populations, but...
6.
Wander C, Li Y, Bao H, Asrican B, Luo Y, Sullivan H, et al.
J Transl Med
. 2023 Apr;
21(1):258.
PMID: 37061718
Background: Alzheimer's disease (AD) is characterized by a progressive loss of memory that cannot be efficiently managed by currently available AD therapeutics. So far, most treatments for AD that have...
7.
Jin L, Matsuyama M, Sullivan H, Zhu M, Lavin T, Hou Y, et al.
Proc Natl Acad Sci U S A
. 2023 Apr;
120(7):e2023481120.
PMID: 37053554
Monosynaptic tracing using rabies virus is an important technique in neuroscience, allowing brain-wide labeling of neurons directly presynaptic to a targeted neuronal population. A 2017 article reported the development of...
8.
Zhang A, Jin L, Yao S, Matsuyama M, van Velthoven C, Sullivan H, et al.
bioRxiv
. 2023 Mar;
PMID: 36993334
Mapping the connectivity of diverse neuronal types provides the foundation for understanding the structure and function of neural circuits. High-throughput and low-cost neuroanatomical techniques based on RNA barcode sequencing have...
9.
Xiao C, Wei J, Zhang G, Tao C, Huang J, Shen L, et al.
Neuron
. 2023 Mar;
111(9):1486-1503.e7.
PMID: 36893756
Extracting the valence of environmental cues is critical for animals' survival. How valence in sensory signals is encoded and transformed to produce distinct behavioral responses remains not well understood. Here,...
10.
Adaikkan C, Wang J, Abdelaal K, Middleton S, Bozzelli P, Wickersham I, et al.
Neuron
. 2022 Aug;
110(19):3091-3105.e9.
PMID: 35987206
A major pathological hallmark of neurodegenerative diseases, including Alzheimer's, is a significant reduction in the white matter connecting the two cerebral hemispheres, as well as in the correlated activity between...