Cardiac Arrhythmia: a Simple Conceptual Framework

Overview

Journal Trends Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2010 Dec 7

PMID 21130954

Citations 9

Authors

Asli Kalin

Juliet Usher-Smith

Victoria J Jones

Christopher L-H Huang

Ian N Sabir

Affiliations

Soon will be listed here.

Abstract

This review presents a simple trigger-substrate model of arrhythmogenesis and its application to the generation of reentrant ventricular arrhythmias. We demonstrate its broad applicability to the understanding of arrhythmic phenomena in a wide range of both hereditary and acquired arrhythmic disorders.

Citing Articles

Mitochondrial Dysfunction Increases Arrhythmic Triggers and Substrates; Potential Anti-arrhythmic Pharmacological Targets.

Saadeh K, Fazmin I Front Cardiovasc Med. 2021; 8:646932.

PMID: 33659284 PMC: 7917191. DOI: 10.3389/fcvm.2021.646932.

Reduced cardiomyocyte Na current in the age-dependent murine Pgc-1β model of ventricular arrhythmia.

Ahmad S, Valli H, Smyth R, Jiang A, Jeevaratnam K, Matthews H J Cell Physiol. 2018; 234(4):3921-3932.

PMID: 30146680 PMC: 6492124. DOI: 10.1002/jcp.27183.

Arrhythmogenic mechanisms of obstructive sleep apnea in heart failure patients.

Chadda K, Fazmin I, Ahmad S, Valli H, Edling C, Huang C Sleep. 2018; 41(9).

PMID: 30016501 PMC: 6132629. DOI: 10.1093/sleep/zsy136.

Cardiomyocyte ionic currents in intact young and aged murine Pgc-1β atrial preparations.

Valli H, Ahmad S, Jiang A, Smyth R, Jeevaratnam K, Matthews H Mech Ageing Dev. 2017; 169:1-9.

PMID: 29197478 PMC: 5846848. DOI: 10.1016/j.mad.2017.11.016.

Trigger vs. Substrate: Multi-Dimensional Modulation of QT-Prolongation Associated Arrhythmic Dynamics by a hERG Channel Activator.

Colman M, Alday E, Holden A, Benson A Front Physiol. 2017; 8:757.

PMID: 29046643 PMC: 5632683. DOI: 10.3389/fphys.2017.00757.