Ian K Campbell
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Explore the profile of Ian K Campbell including associated specialties, affiliations and a list of published articles.
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26
Citations
1363
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Recent Articles
1.
Almizraq R, Boligan K, Lewis B, Cen S, Whetstone H, Spirig R, et al.
Pharmacology
. 2023 Jan;
108(2):176-187.
PMID: 36696888
Introduction: Neutrophils are a pivotal cell type in the K/BxN mouse model of rheumatoid arthritis and play an essential role in the progression of the arthritis. They are readily activated...
2.
Crow A, Kapur R, Koernig S, Campbell I, Jen C, Mott P, et al.
Sci Transl Med
. 2019 Aug;
11(506).
PMID: 31434758
Treatment of autoimmune and inflammatory diseases typically involves immune suppression. In an opposite strategy, we show that administration of the highly inflammatory erythrocyte-specific antibody Ter119 into mice remodels the monocyte...
3.
Koernig S, Campbell I, Mackenzie-Kludas C, Schaub A, Loetscher M, Ng W, et al.
Mucosal Immunol
. 2019 May;
12(4):1013-1024.
PMID: 31105268
Recurrent and persistent airway infections remain prevalent in patients with primary immunodeficiency (PID), despite restoration of serum immunoglobulin levels by intravenous or subcutaneous plasma-derived IgG. We investigated the effectiveness of...
4.
Spirig R, Campbell I, Koernig S, Chen C, Lewis B, Butcher R, et al.
J Immunol
. 2018 Mar;
200(8):2542-2553.
PMID: 29531170
Activation of Fc receptors and complement by immune complexes is a common important pathogenic trigger in many autoimmune diseases and so blockade of these innate immune pathways may be an...
5.
Campbell I, Leong D, Edwards K, Rayzman V, Ng M, Goldberg G, et al.
J Immunol
. 2016 Nov;
197(11):4392-4402.
PMID: 27807194
G-CSF is a hemopoietic growth factor that has a role in steady state granulopoiesis, as well as in mature neutrophil activation and function. G-CSF- and G-CSF receptor-deficient mice are profoundly...
6.
Goldberg G, Cornish A, Murphy J, Pang E, Lim L, Campbell I, et al.
Am J Pathol
. 2016 Jan;
186(1):172-84.
PMID: 26718978
Granulocyte colony-stimulating factor (G-CSF) is a regulator of neutrophil production, function, and survival. Herein, we investigated the role of G-CSF in a murine model of human uveitis-experimental autoimmune uveoretinitis. Experimental...
7.
Liu X, Croker B, Campbell I, Gauci S, Alexander W, Tonkin B, et al.
Arthritis Rheumatol
. 2014 May;
66(9):2391-402.
PMID: 24839265
Objective: To examine the impact of the gp130 cytokine family on murine articular cartilage and to explore a potential regulatory role of suppressor of cytokine signaling 3 (SOCS-3) in murine...
8.
Campbell I, Miescher S, Branch D, Mott P, Lazarus A, Han D, et al.
J Immunol
. 2014 Apr;
192(11):5031-8.
PMID: 24760152
High-dose i.v. Ig (IVIG) is used to treat various autoimmune and inflammatory diseases; however, the mechanism of action remains unclear. Based on the K/BxN serum transfer arthritis model in mice,...
9.
Lawlor K, Van Nieuwenhuijze A, Parker K, Drake S, Campbell I, Smith S, et al.
J Leukoc Biol
. 2013 Jan;
93(4):585-97.
PMID: 23341540
RA is a chronic autoimmune disease characterized by accumulation of inflammatory cells within synovial joints. RA is associated with a failure of apoptosis of infiltrating leukocytes, thought to be a...
10.
Campbell I, Van Nieuwenhuijze A, Segura E, ODonnell K, Coghill E, Hommel M, et al.
J Immunol
. 2011 Mar;
186(9):5468-77.
PMID: 21421852
Rel/NF-κB transcription factors regulate inflammatory and immune responses. Despite possible subunit redundancy, NF-κB1-deficient (Nfkb1(-/-)) mice were profoundly protected from sterile CD4 T cell-dependent acute inflammatory arthritis and peritonitis. We evaluated...