Ian Jackson
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Explore the profile of Ian Jackson including associated specialties, affiliations and a list of published articles.
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42
Citations
4253
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Recent Articles
11.
Jackson I, Addasi Y, Ahmed M, Ramadan B, Kalian K, Addasi N, et al.
Case Rep Endocrinol
. 2021 Jul;
2021:4529009.
PMID: 34239739
Background: Hypokalemic periodic paralysis is a rare neuromuscular disorder characterized by transient episodes of flaccid paralysis due to a defect in muscle ion channels. Most cases are hereditary, but it...
12.
Goldberg R, Clough J, Roberts L, Sanchez J, Kordasti S, Petrov N, et al.
J Crohns Colitis
. 2021 Jun;
15(12):2054-2065.
PMID: 34120187
Background And Aims: Differential responsiveness to interleukin [IL]-2 between effector CD4+ T cells [Teff] and regulatory T cells [Treg] is a fundamental mechanism of immunoregulation. The single nucleotide polymorphism [SNP]...
13.
Roberts L, Jowett G, Read E, Zabinski T, Berkachy R, Selkirk M, et al.
J Immunol
. 2021 May;
206(11):2725-2739.
PMID: 34021046
Innate lymphoid cells are central to the regulation of immunity at mucosal barrier sites, with group 2 innate lymphoid cells (ILC2s) being particularly important in type 2 immunity. In this...
14.
Sanchez J, Jackson I, Flaherty K, Muliaditan T, Schurich A
Metabolites
. 2020 Nov;
10(11).
PMID: 33202938
Upon activation T cells engage glucose metabolism to fuel the costly effector functions needed for a robust immune response. Consequently, the availability of glucose can impact on T cell function....
15.
Pennamen P, Tingaud-Sequeira A, Gazova I, Keighren M, McKie L, Marlin S, et al.
Genet Med
. 2020 Oct;
23(3):479-487.
PMID: 33100333
Purpose: Albinism is a clinically and genetically heterogeneous condition. Despite analysis of the 20 known genes, ~30% patients remain unsolved. We aimed to identify new genes involved in albinism. Methods:...
16.
Anandagoda N, Roberts L, Willis J, Sarathchandra P, Xiao F, Jackson I, et al.
Am J Transplant
. 2020 Apr;
20(10):2715-2727.
PMID: 32277570
Organ transplantation is often lifesaving, but the long-term deleterious effects of combinatorial immunosuppression regimens and allograft failure cause significant morbidity and mortality. Long-term graft survival in the absence of continuing...
17.
Anandagoda N, Willis J, Hertweck A, Roberts L, Jackson I, Gokmen M, et al.
J Clin Invest
. 2019 Feb;
129(3):1257-1271.
PMID: 30741720
Tregs play a fundamental role in immune tolerance via control of self-reactive effector T cells (Teffs). This function is dependent on maintenance of a high intracellular cAMP concentration. A number...
18.
Hertweck A, Evans C, Eskandarpour M, Lau J, Oleinika K, Jackson I, et al.
Cell Rep
. 2016 Jun;
15(12):2756-70.
PMID: 27292648
The transcription factor T-bet directs Th1 cell differentiation, but the molecular mechanisms that underlie this lineage-specific gene regulation are not completely understood. Here, we show that T-bet acts through enhancers...
19.
20.
Gokmen M, Dong R, Kanhere A, Powell N, Perucha E, Jackson I, et al.
J Immunol
. 2013 Nov;
191(12):5925-32.
PMID: 24249732
The complex relationship between Th1 and Th17 cells is incompletely understood. The transcription factor T-bet is best known as the master regulator of Th1 lineage commitment. However, attention is now...