Esperanza Perucha
Overview
Explore the profile of Esperanza Perucha including associated specialties, affiliations and a list of published articles.
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22
Citations
1169
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Recent Articles
1.
Coyle C, Ma M, Abraham Y, Mahony C, Steel K, Simpson C, et al.
JCI Insight
. 2024 Oct;
9(23).
PMID: 39418106
Rheumatoid arthritis (RA) is an immune-mediated, chronic inflammatory condition. With modern therapeutics and evidence-based management strategies, achieving sustained remission is increasingly common. To prevent complications associated with prolonged use of...
2.
Patel A, Willsmore Z, Khan N, Richter A, Naidu B, Drayson M, et al.
Nat Commun
. 2022 Jun;
13(1):3148.
PMID: 35672305
Checkpoint blockade with Pembrolizumab, has demonstrated durable clinical responses in advanced non-small cell lung cancer, however, treatment is offset by the development of high-grade immune related adverse events (irAEs) in...
3.
Ribeiro F, Perucha E, Graca L
Immunol Lett
. 2022 Mar;
244:1-11.
PMID: 35227735
The formation of high-affinity antibodies that protect against infection requires the formation of germinal centres (GCs), where specialized T follicular helper cells (Tfh) provide help to B cells. Those T-B...
4.
Lista M, Matos P, Maguire T, Poulton K, Ortiz-Zapater E, Page R, et al.
PLoS One
. 2021 Sep;
16(9):e0256813.
PMID: 34525109
There is a worldwide need for reagents to perform SARS-CoV-2 detection. Some laboratories have implemented kit-free protocols, but many others do not have the capacity to develop these and/or perform...
5.
Cardoso D, Perucha E
Clin Sci (Lond)
. 2021 Jun;
135(11):1389-1408.
PMID: 34086048
The immune system protects the body against harm by inducing inflammation. During the immune response, cells of the immune system get activated, divided and differentiated in order to eliminate the...
6.
Lista M, Matos P, Maguire T, Poulton K, Ortiz-Zapater E, Page R, et al.
medRxiv
. 2021 Apr;
PMID: 33851184
There is a worldwide need for reagents to perform SARS-CoV-2 detection. Some laboratories have implemented kit-free protocols, but many others do not have the capacity to develop these and/or perform...
7.
Bibby J, Purvis H, Hayday T, Chandra A, Okkenhaug K, Rosenzweig S, et al.
Nat Commun
. 2020 Jul;
11(1):3412.
PMID: 32641742
Regulatory B cells restrict immune and inflammatory responses across a number of contexts. This capacity is mediated primarily through the production of IL-10. Here we demonstrate that the induction of...
8.
Ibraheim H, Perucha E, Powell N
Rheumatology (Oxford)
. 2019 Dec;
58(Suppl 7):vii17-vii28.
PMID: 31816081
Immune check point inhibitor (CPI) therapy has revolutionized treatment paradigms for several cancers, but at the cost of triggering a diverse spectrum of immune-mediated injury to non-cancer tissues. The complex...
9.
Perucha E, Melchiotti R, Bibby J, Wu W, Frederiksen K, Roberts C, et al.
Nat Commun
. 2019 Feb;
10(1):498.
PMID: 30700717
The mechanisms controlling CD4 T cell switching from an effector to an anti-inflammatory (IL-10) phenotype play an important role in the persistence of chronic inflammatory diseases. Here, we identify the...
10.
Hernandez-Fuentes M, Franklin C, Rebollo-Mesa I, Mollon J, Delaney F, Perucha E, et al.
Am J Transplant
. 2018 Feb;
18(6):1370-1379.
PMID: 29392897
Improvements in immunosuppression have modified short-term survival of deceased-donor allografts, but not their rate of long-term failure. Mismatches between donor and recipient HLA play an important role in the acute...