Iakov I Davydov
Overview
Explore the profile of Iakov I Davydov including associated specialties, affiliations and a list of published articles.
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10
Citations
250
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Recent Articles
1.
Roller A, Davydov I, Schwalie P, Serrano-Serrano M, Heller A, Staedler N, et al.
J Immunother Cancer
. 2024 Apr;
12(4).
PMID: 38649280
Background: The immune status of a patient's tumor microenvironment (TME) may guide therapeutic interventions with cancer immunotherapy and help identify potential resistance mechanisms. Currently, patients' immune status is mostly classified...
2.
Melero I, Tanos T, Bustamante M, Sanmamed M, Calvo E, Moreno I, et al.
Sci Transl Med
. 2023 May;
15(695):eabp9229.
PMID: 37163618
This first-in-human study evaluated RO7122290, a bispecific fusion protein carrying a split trimeric 4-1BB (CD137) ligand and a fibroblast activation protein α (FAP) binding site that costimulates T cells for...
3.
Natoli M, Hatje K, Gulati P, Junker F, Herzig P, Jiang Z, et al.
J Immunother Cancer
. 2022 Nov;
10(11).
PMID: 36319064
Background: Next-generation cancer immunotherapies are designed to broaden the therapeutic repertoire by targeting new immune checkpoints including lymphocyte-activation gene 3 (LAG-3) and T cell immunoglobulin and mucin-domain containing-3 (TIM-3). Yet,...
4.
Badillo S, Banfai B, Birzele F, Davydov I, Hutchinson L, Kam-Thong T, et al.
Clin Pharmacol Ther
. 2020 Mar;
107(4):871-885.
PMID: 32128792
In the last few years, machine learning (ML) and artificial intelligence have seen a new wave of publicity fueled by the huge and ever-increasing amount of data and computational power...
5.
Yamada K, Davydov I, Besnard G, Salamin N
J Exp Bot
. 2019 Sep;
70(21):6127-6139.
PMID: 31498865
Ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) is considered to be the main enzyme determining the rate of photosynthesis. The small subunit of the protein, encoded by the rbcS gene, has been shown to...
6.
Davydov I, Salamin N, Robinson-Rechavi M
Mol Biol Evol
. 2019 Mar;
36(6):1316-1332.
PMID: 30847475
There are numerous sources of variation in the rate of synonymous substitutions inside genes, such as direct selection on the nucleotide sequence, or mutation rate variation. Yet scans for positive...
7.
Bochkareva O, Moroz E, Davydov I, Gelfand M
BMC Genomics
. 2018 Dec;
19(1):965.
PMID: 30587126
Background: The genus Burkholderia consists of species that occupy remarkably diverse ecological niches. Its best known members are important pathogens, B. mallei and B. pseudomallei, which cause glanders and melioidosis,...
8.
Davydov I, Robinson-Rechavi M, Salamin N
Bioinformatics
. 2017 Feb;
33(3):354-362.
PMID: 28172542
Motivation: Codon models are widely used to identify the signature of selection at the molecular level and to test for changes in selective pressure during the evolution of genes encoding...
9.
Bock L, Blau C, Schroder G, Davydov I, Fischer N, Stark H, et al.
Nat Struct Mol Biol
. 2013 Nov;
20(12):1390-6.
PMID: 24186064
During protein synthesis, tRNAs move from the ribosome's aminoacyl to peptidyl to exit sites. Here we investigate conformational motions during spontaneous translocation, using molecular dynamics simulations of 13 intermediate-translocation-state models...
10.
Davydov I, Wohlgemuth I, Artamonova I, Urlaub H, Tonevitsky A, Rodnina M
Nat Commun
. 2013 Jan;
4:1387.
PMID: 23340427
The emergence of ribosomes and translation factors is central for understanding the origin of life. Recruitment of translation factors to bacterial ribosomes is mediated by the L12 stalk composed of...