I Shiojima
Overview
Explore the profile of I Shiojima including associated specialties, affiliations and a list of published articles.
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Articles
46
Citations
1325
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Recent Articles
1.
Sakurai S, Takenaka K, Shiojima I, Watanabe F, Sonoda M, Uno K, et al.
Echocardiography
. 2001 Jun;
18(4):303-4.
PMID: 11415501
No abstract available.
2.
Morales-Ruiz M, Lee M, Zollner S, Gratton J, Scotland R, Shiojima I, et al.
J Biol Chem
. 2001 Mar;
276(22):19672-7.
PMID: 11278592
Sphingosine 1-phosphate (SPP) binds to members of the endothelial differentiation gene family (EDG) of receptors and leads to diverse signaling events including cell survival, growth, migration and differentiation. However, the...
3.
Kureishi Y, Luo Z, Shiojima I, Bialik A, Fulton D, Lefer D, et al.
Nat Med
. 2000 Sep;
6(9):1004-10.
PMID: 10973320
Recent studies suggest that statins can function to protect the vasculature in a manner that is independent of their lipid-lowering activity. We show here that statins rapidly activate the protein...
4.
Zhu W, Shiojima I, Hiroi Y, Zou Y, Akazawa H, Mizukami M, et al.
J Biol Chem
. 2000 Aug;
275(45):35291-6.
PMID: 10948187
A homeodomain-containing transcription factor Csx/Nkx-2.5 is an important regulator of cardiogenesis in mammals. Three different mutants, Gln170ter (designated A) and Thr178Met (designated B) in the helix 2 of the homeodomain...
5.
Hosoda T, Komuro I, Shiojima I, Hiroi Y, Harada M, Murakawa Y, et al.
Jpn Circ J
. 2000 Aug;
63(5):425-6.
PMID: 10943630
Atrial septal defect (ASD) is the most common form of congenital cardiac defect in humans. Recently, point mutations in the cardiac homeobox gene CSX/NKX2-5 have been reported to cause the...
6.
Shiojima I, Oka T, Hiroi Y, Nagai R, Yazaki Y, Komuro I
Biochem Biophys Res Commun
. 2000 Jun;
272(3):749-57.
PMID: 10860827
Cardiac homeobox gene Csx/Nkx-2.5 is essential for normal heart development and morphogenesis and is the earliest marker for cardiogenesis. To elucidate the regulatory mechanisms of Csx/Nkx-2.5 expression, we have isolated...
7.
Zhu W, Zou Y, Shiojima I, Kudoh S, Aikawa R, Hayashi D, et al.
J Biol Chem
. 2000 May;
275(20):15239-45.
PMID: 10809760
Endothelin-1 (ET-1) induces cardiac hypertrophy. Because Ca(2+) is a major second messenger of ET-1, the role of Ca(2+) in ET-1-induced hypertrophic responses in cultured cardiac myocytes of neonatal rats was...
8.
Takimoto E, Mizuno T, Terasaki F, Shimoyama M, Honda H, Shiojima I, et al.
Biochem Biophys Res Commun
. 2000 Apr;
270(3):1074-9.
PMID: 10772952
A cardiac homeobox-containing gene Csx/Nkx2-5, which is essential for cardiac development, is abundantly expressed in the adult heart as well as in the heart primordia. Targeted disruption of this gene...
9.
Oka T, Shiojima I, Monzen K, Kudoh S, Hiroi Y, Shiokawa K, et al.
Arterioscler Thromb Vasc Biol
. 2000 Apr;
20(4):907-14.
PMID: 10764653
Although smooth muscle cells (SMCs) are critical components of the circulatory system, the regulatory mechanisms of SMC differentiation remain largely unknown. In the present study, we examined the mechanism of...
10.
Shiojima I, Aikawa M, Suzuki J, Yazaki Y, Nagai R
Jpn Heart J
. 2000 Mar;
40(6):803-18.
PMID: 10737564
Left ventricular hypertrophy (LVH) is a secondary adaptation to increased external load. Various qualitative and quantitative changes in myocytes and extracellular components occur during the development of LVH. It has...