I Rozas
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Explore the profile of I Rozas including associated specialties, affiliations and a list of published articles.
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14
Citations
37
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Recent Articles
1.
de la Puente S, Espinoza M, Carrillo I, Rico C, Souto H, Acedo J, et al.
Cir Pediatr
. 2023 Jul;
36(3):128-134.
PMID: 37417217
Objective: To analyze the risk factors associated with hemorrhagic cystitis (HC) severity and the treatment strategies available in HC patients following allogeneic hematopoietic stem cell transplantation (AHSCT). Materials And Methods:...
2.
Dardonville C, Goya P, Rozas I, Alsasua A, Martin M, Borrego M
Bioorg Med Chem
. 2000 Sep;
8(7):1567-77.
PMID: 10976505
The design, synthesis and alpha1-adrenoceptor antagonism of a series of bis-imidazoline (1a, 2a, 3a and 4a) and bis-guanidine (1b, 2b, 3b and 4b) diphenyl derivatives are reported. All of these...
3.
Dardonville C, Rozas I, Alkorta I
J Mol Graph Model
. 1999 Aug;
16(3):150-6, 166-7.
PMID: 10434255
Bradykinin (BK) is a potent nociceptive agent and its antagonists show analgesic activity. In the search for new antagonists of BK, the design of nonpeptidic derivatives with different terminal cations...
4.
Alcalde E, Barat A, Goya P, Martinez A, Ramirez G, Roca T, et al.
Bioorg Med Chem
. 1997 May;
5(5):949-54.
PMID: 9208104
A new type of extended pi-system aza-analogue of (E)-4-[2-(1-naphthylvinyl)]-1-substituted pyridinium salts (NVP+) has been designed and its inhibitory activity towards choline acetyltransferase (ChAT) has been evaluated in vitro. Among the...
5.
Rozas I, Du Q, Arteca G
J Mol Graph
. 1995 Apr;
13(2):98-108.
PMID: 7619791
Molecular electrostatics and lipophilicity are two important properties included in quantitative structure-activity relationships (QSARs) employed for rational drug design. The molecular electrostatic potential (MEP) provides information on the position, distribution,...
6.
Rozas I, Martin M
J Mol Graph
. 1994 Dec;
12(4):267-74, 290-1.
PMID: 7696217
Shape analysis methodology is applied to the study of 4-alkylpyrazoles which are known inhibitors of liver alcohol dehydrogenase. Elongation of the alkyl chain increases the inhibitory power, whereas branching of...
7.
Echevarria A, Martin M, Perez C, Rozas I
Arch Pharm (Weinheim)
. 1994 May;
327(5):303-5.
PMID: 8010882
Theoretical studies by shape analysis of the molecular electrostatic potential on the van der Waals surfaces of a set of 4-alkylpyrazoles predicted 4-isopentyl derivative as a good inhibitor of liver...
8.
Camina M, Rozas I, Castro-Gago M, Paz J, Alonso C, Rodriguez-Segade S
Neurology
. 1991 Sep;
41(9):1444-8.
PMID: 1891096
We administered therapeutic doses of valproic acid (VPA), carbamazepine (CBZ), phenytoin (PHT), and phenobarbital (PHB) to mice for 7 days, and 8 hours after the final dose we measured the...
9.
Camina M, Rozas I, Gomez M, Paz J, Alonso C, Rodriguez-Segade S
Br J Pharmacol
. 1991 May;
103(1):1179-83.
PMID: 1878756
1. The short-term evolution of concentrations of free carnitine and acylcarnitine was studied in the serum, liver, kidney, heart and skeletal muscle of mice after administration of single therapeutic doses...
10.
Alonso de la Pena C, Rozas I, Pardinas M, Paz J, Rodriguez-Segade S
Biochem Med Metab Biol
. 1990 Aug;
44(1):77-83.
PMID: 2390292
We report the free, acyl-, and total carnitine contents of 49 clinically healthy volunteers and 167 chronic alcoholics with various clinically and/or anatomopathologically identified degrees of hepatic affection. There was...