I R Lemischka
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Explore the profile of I R Lemischka including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
1783
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Recent Articles
21.
Lemischka I
Curr Opin Genet Dev
. 1993 Feb;
3(1):115-8.
PMID: 8453269
Retroviral vectors have been widely employed in gene transfer studies in higher organisms. One application has been in cell lineage studies. The last several years have seen the extension of...
22.
Lemischka I
Cancer Surv
. 1992 Jan;
15:3-18.
PMID: 1451112
Transplantation and marking studies have provided an accurate description of various aspects of developmental and proliferative behaviour of totipotent haematopoietic stem cells. In particular, the remarkable ability of different clones...
23.
24.
Lemischka I
Semin Immunol
. 1991 Nov;
3(6):349-55.
PMID: 1686833
Classical and more recent studies have provided a description of the in vivo behavior of the totipotent hematopoietic stem cell and its clonal progeny. These reconstitution experiments, employing clonotypic markers...
25.
Matthews W, Jordan C, Gavin M, Jenkins N, Copeland N, Lemischka I
Proc Natl Acad Sci U S A
. 1991 Oct;
88(20):9026-30.
PMID: 1717995
We have cloned a receptor tyrosine kinase cDNA, designated fetal liver kinase 1 (Flk-1), from mouse cell populations enriched for hematopoietic stem and progenitor cells. Sequence analysis of this clone...
26.
Matthews W, Jordan C, Wiegand G, Pardoll D, Lemischka I
Cell
. 1991 Jun;
65(7):1143-52.
PMID: 1648448
To elucidate the molecular biology of the hematopoietic stem cell, we have begun to isolate genes from murine cell populations enriched in stem cell activity. One such cDNA encodes a...
27.
Jordan C, McKearn J, Lemischka I
Cell
. 1990 Jun;
61(6):953-63.
PMID: 1972037
We have characterized the fetal totipotent hematopoietic stem cell using a novel strategy that integrates physical analysis of cell properties and genetic analysis of in vivo developmental behavior. This approach...
28.
Jordan C, Lemischka I
Genes Dev
. 1990 Feb;
4(2):220-32.
PMID: 1970972
We have analyzed the temporal in vivo fate of 142 individual stem cell clones in 63 reconstituted mice. Long-term sequential analyses of the four major peripheral blood lineages, obtained from...
29.
Lemischka I, Raulet D, Mulligan R
Cell
. 1986 Jun;
45(6):917-27.
PMID: 2871944
We have used retrovirus-mediated gene transfer to mark hematopoietic stem cells in vitro and have tracked the fate of these cells after their transplantation into lethally irradiated recipients. Several classes...
30.
Roberts B, Miller J, Kimelman D, Cepko C, Lemischka I, Mulligan R
J Virol
. 1985 Nov;
56(2):404-13.
PMID: 4057356
Adenovirus early region 1A (E1A), which gives rise to three overlapping transcripts, was inserted into a murine leukemia virus-derived vector, and recombinant viruses were used to prepare permanent cell lines...