I R Lemischka
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Explore the profile of I R Lemischka including associated specialties, affiliations and a list of published articles.
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33
Citations
1783
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Recent Articles
11.
Fiorino A, Diehl A, Lin H, Lemischka I, Reid L
In Vitro Cell Dev Biol Anim
. 1998 Apr;
34(3):247-58.
PMID: 9557943
We have isolated a conditionally transformed liver progenitor cell line with phenotypic similarities to both hepatoblasts (bipotent embryonic liver cells that give rise to hepatocytes and intrahepatic biliary epithelial cells)...
12.
Moore K, Ema H, Lemischka I
Blood
. 1997 Jun;
89(12):4337-47.
PMID: 9192756
The cellular and molecular mechanisms that regulate the most primitive hematopoietic stem cell are not well understood. We have undertaken a systematic dissection of the complex hematopoietic microenvironment to define...
13.
Moore K, Pytowski B, Witte L, Hicklin D, Lemischka I
Proc Natl Acad Sci U S A
. 1997 Apr;
94(8):4011-6.
PMID: 9108096
Primitive hematopoietic stem cells are closely associated with discrete in vivo microenvironments. These "niches" are thought to provide the molecular signals that mediate stem cell differentiation and self-renewal. We have...
14.
Harrison D, Zhong R, Jordan C, Lemischka I, Astle C
Exp Hematol
. 1997 Apr;
25(4):293-7.
PMID: 9131003
Multilineage precursor cells from 14-day B6 (C57B1/6J) mouse fetal liver and adult bone marrow that repopulate both the lymphoid and myeloid systems were compared by competitive repopulation. Cells were assayed...
15.
Lemischka I
Stem Cells
. 1997 Jan;
15 Suppl 1:63-8.
PMID: 9368326
A major challenge in hematopoietic biology is the description and understanding of the molecular mechanisms responsible for the regulation of the primitive stem cell compartment. In one sense there exists...
16.
Dosil M, Leibman N, Lemischka I
Blood
. 1996 Dec;
88(12):4510-25.
PMID: 8977243
We report the isolation of cDNAs encoding protein tyrosine phosphatases (PTPs) from highly purified hematopoietic stem cell populations. One such cDNA encodes a novel PTP, designated fetal liver phosphatase 1...
17.
Jordan C, Astle C, Zawadzki J, Mackarehtschian K, Lemischka I, Harrison D
Exp Hematol
. 1995 Aug;
23(9):1011-5.
PMID: 7635180
To characterize hematopoietic cell biology, many investigators have used protocols that enrich for primitive hematopoietic stem cells (PHSC). In this study, we quantified the long-term repopulating ability (LTRA) of enriched...
18.
Mackarehtschian K, Hardin J, Moore K, Boast S, Goff S, Lemischka I
Immunity
. 1995 Jul;
3(1):147-61.
PMID: 7621074
The flk2 receptor tyrosine kinase has been implicated in hematopoietic development. Mice deficient in flk2 were generated. Mutants developed into healthy adults with normal mature hematopoietic populations. However, they possessed...
19.
Tessler S, Rockwell P, Hicklin D, Cohen T, Levi B, Witte L, et al.
J Biol Chem
. 1994 Apr;
269(17):12456-61.
PMID: 8175651
The 165-amino acid form of vascular endothelial growth factor (VEGF165) is a mitogen for vascular endothelial cells and a potent angiogenic factor. Expression of a chimeric receptor containing the extracellular...
20.
Dosil M, Wang S, Lemischka I
Mol Cell Biol
. 1993 Oct;
13(10):6572-85.
PMID: 7692230
Flk2/Flt3 is a recently identified receptor tyrosine kinase expressed in brain, placenta, testis, and primitive hematopoietic cells. The mitogenic signalling potential and biochemical properties of Flk2/Flt3 have been analyzed by...