I Irwin
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Explore the profile of I Irwin including associated specialties, affiliations and a list of published articles.
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83
Citations
2459
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Recent Articles
1.
Irwin I
Pharm Res
. 2013 Nov;
3(1):7-11.
PMID: 24271351
Since the recognition that the compound l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP) is a potent inducer of chronic and irreversible parkinsonism in humans, it has been the object of intense and extensive research activity....
2.
Choppin A, Irwin I, Lach L, McDonald M, Rettie A, Shao L, et al.
Br J Pharmacol
. 2009 Oct;
158(6):1536-47.
PMID: 19845677
Background And Purpose: Tecarfarin (ATI-5923) is a novel vitamin K epoxide reductase inhibitor that is metabolized by esterase (mainly human carboxylesterase 2) to a single major metabolite, ATI-5900, in rats,...
3.
Yee R, Irwin I, Milonas C, Stout D, Huang S, Satyamurthy N, et al.
Mov Disord
. 2001 Dec;
16(5):838-48.
PMID: 11746613
Striatal 6-[18F]fluoro-L-DOPA (FDOPA) kinetic rate constants were measured by positron emission tomography (PET) in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated squirrel monkeys. After scanning, stereological counts of dopaminergic neurons were done in substantia nigra,...
4.
Pulliam L, Irwin I, Kusdra L, Rempel H, Flitter W, Garland W
Brain Res
. 2001 Feb;
893(1-2):95-103.
PMID: 11222997
Individuals infected with the human immunodeficiency virus (HIV) often experience a dementia characterized by mental slowing and memory loss. Motor dysfunction may also accompany this condition. The pathogenesis of the...
5.
McGrew D, Irwin I, Langston J
Neurotoxicology
. 2000 Jul;
21(3):309-12.
PMID: 10894120
Diethyldithiocarbamate (DDC) has been shown to enhance 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced striatal dopamine depletion in mice. Surprisingly, although DDC is a prototypic member of a class of compounds called dithiocarbamates (DTCs) that...
6.
Hensley K, Robinson K, Pye Q, Floyd R, Cheng I, Garland W, et al.
Neurosci Lett
. 2000 Mar;
281(2-3):179-82.
PMID: 10704772
The p38 mitogen-activated protein kinase (p38-MAPK) is a central enzyme in one of the major protein kinase cascades that regulate proapoptotic and proinflammatory signal transduction. p38-MAPK is activated by receptor/ligand...
7.
Yee R, Huang S, Stout D, Irwin I, Togaski D, DELANNEY L, et al.
J Neurochem
. 2000 Feb;
74(3):1147-57.
PMID: 10693947
Aromatic L-amino acid decarboxylase (AAAD) activity was examined in vivo with positron emission tomography (PET) using 6-[18F]fluoro-L-DOPA (FDOPA) in squirrel monkeys lesioned with graded doses of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)....
8.
Walters T, Irwin I, Delfani K, Langston J, Janson A
Exp Neurol
. 1999 Apr;
156(1):62-70.
PMID: 10192777
Although nontoxic when administered alone, diethyldithiocarbamate (DDC) is known to enhance the dopamine-depleting effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse striatum. The purpose of the present study was twofold: (i)...
9.
Irwin I, Delanney L, Chan P, Sandy M, Di Monte D, Langston J
Neurobiol Aging
. 1997 Mar;
18(2):235-41.
PMID: 9258902
In this study we assessed the two forms of monoamine oxidase (MAO) in the caudate, putamen, and substantia nigra of young (4-year-old), intermediate-aged (11-year-old), and aged (20-year-old) squirrel monkeys and...
10.
Di Monte D, DELANNEY L, Irwin I, Royland J, Chan P, Jakowec M, et al.
Brain Res
. 1996 Oct;
738(1):53-9.
PMID: 8949927
The effects of monoamine oxidase (MAO) inhibitors on the metabolism of dopamine synthesized from exogenous L-DOPA were investigated in the striatum and substantia nigra of squirrel monkeys. Administration of a...