I C MacLennan
Overview
Explore the profile of I C MacLennan including associated specialties, affiliations and a list of published articles.
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192
Citations
4318
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Recent Articles
1.
MacLennan I, Gray D, Kumararatne D, Bazin H
Immunol Today
. 2014 Oct;
3(11):305-7.
PMID: 25290472
In a recent article on B-cell development Klinman and his colleagues asked the question 'Do B cells exist as separate lineages?'. Studies of B cells in rat spleen support on...
2.
Vinuesa C, Sunners Y, Pongracz J, Ball J, Toellner K, Taylor D, et al.
Eur J Immunol
. 2001 Jul;
31(5):1340-50.
PMID: 11465091
X-linked immunodeficient (Xid) mice carry a Bruton's tyrosine kinase (Btk) mutation and exhibit a selective failure to produce antibodies against bacterial capsular polysaccharides. Studies in vitro point to a fundamental...
3.
McCloskey E, Dunn J, Kanis J, MacLennan I, Drayson M
Br J Haematol
. 2001 Jul;
113(4):1035-43.
PMID: 11442499
Oral clodronate (1600 mg/d) has been shown to significantly reduce the incidence of skeletal complications in multiple myeloma. Preliminary analysis of a double-blind placebo-controlled trial of this treatment indicated that...
4.
Wehrli N, Legler D, Finke D, Toellner K, Loetscher P, Baggiolini M, et al.
Eur J Immunol
. 2001 Feb;
31(2):609-16.
PMID: 11180126
During T cell-dependent antibody responses lymph node B cells differentiate either to plasmablasts that grow in the medullary cords, or to blasts that proliferate in follicles forming germinal centers. Many...
5.
Sze D, Toellner K, Garcia de Vinuesa C, Taylor D, MacLennan I
J Exp Med
. 2000 Sep;
192(6):813-21.
PMID: 10993912
B cells recruited into splenic antibody responses grow exponentially, either in extrafollicular foci as plasmablasts, or in follicles where they form germinal centers. Both responses yield plasma cells. Although many...
6.
MacLennan I, Garcia de Vinuesa C
Philos Trans R Soc Lond B Biol Sci
. 2000 May;
355(1395):345-50.
PMID: 10794052
Antigens such as viral envelope proteins and bacterial exotoxins induce responses which result in the production of neutralizing antibody. These responses persist for years and provide highly efficient defence against...
7.
de Vinuesa C, Cook M, Ball J, Drew M, Sunners Y, Cascalho M, et al.
J Exp Med
. 2000 Feb;
191(3):485-94.
PMID: 10662794
Germinal centers are critical for affinity maturation of antibody (Ab) responses. This process allows the production of high-efficiency neutralizing Ab that protects against virus infection and bacterial exotoxins. In germinal...
8.
Garcia de Vinuesa C, Khan M, OLeary P, Cascalho M, Wabl M, Klaus G, et al.
Eur J Immunol
. 1999 Nov;
29(11):3712-21.
PMID: 10556827
A subset of myeloid dendritic cells is described which is associated with the ability of splenic and lymph node plasmablasts to survive and differentiate into plasma cells. Plasmablast-associated dendritic cells...
9.
Garcia de Vinuesa C, MacLennan I, Holman M, Klaus G
Eur J Immunol
. 1999 Oct;
29(10):3216-24.
PMID: 10540333
Protection against infection with encapsulated bacteria is mediated by IgG antibodies against the capsular polysaccharides. Production of such antibodies is impaired during infancy, when susceptibility to bacterial meningitis is greatest....
10.
Acha-Orbea H, Finke D, Attinger A, Schmid S, Wehrli N, VACHERON S, et al.
Immunol Rev
. 1999 Jul;
168:287-303.
PMID: 10399081
Mouse mammary tumor virus has developed strategies to exploit the immune response. It requires vigorous immune stimulation to achieve efficient infection. The infected antigen-presenting cells present a viral superantigen on...