I Brockhausen
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Explore the profile of I Brockhausen including associated specialties, affiliations and a list of published articles.
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63
Citations
1120
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Recent Articles
1.
Falconer D, Phillippopoulos K, Czuchry D, Kocev A, Brockhausen I
Carbohydr Res
. 2025 Feb;
552:109434.
PMID: 40020433
Antibiotic resistance is on the rise, making bacterial infections an increasing threat to human health. O-antigenic polysaccharides are important virulence factors of pathogenic Gram-negative bacteria that can be involved in...
2.
Yang X, Yip J, Harrison M, Brockhausen I
Int J Biochem Cell Biol
. 2007 Oct;
40(3):471-83.
PMID: 17931955
Bone cells produce many glycoproteins potentially involved in the maintenance of healthy bone tissues. Two cytokines produced in inflamed joints, tumor necrosis factor (TNF)alpha and transforming growth factor (TGF)beta, have...
3.
Yang X, Yip J, Anastassiades T, Harrison M, Brockhausen I
Biochim Biophys Acta
. 2006 Nov;
1773(2):264-72.
PMID: 17079030
Joint destruction in arthritis is often associated with high levels of inflammatory cytokines. Previous work has shown that inflammatory conditions can alter the activities of glycosyltransferases that synthesize the glycan...
4.
Paulsen H, Brockhausen I
Glycoconj J
. 2003 Jun;
18(11-12):867-70.
PMID: 12820720
This review summarizes fifty years of carbohydrate chemistry, from studies of reaction mechanisms and development of synthetic methods to the design of specific compounds for investigations of cancer glycoproteins. Through...
5.
Brockhausen I
Biochem Soc Trans
. 2003 Mar;
31(2):318-25.
PMID: 12653628
This review summarizes the occurrence, properties and role in mucin O-glycosylation pathways of the various members of glycoprotein sulphotransferase families. Although a number of sulphotransferases have been cloned that act...
6.
Brockhausen I, Vavasseur F, Yang X
Glycoconj J
. 2002 Oct;
18(9):685-97.
PMID: 12386454
Structural differences have been reported in the glycosylation patterns of cystic fibrosis glycoproteins. Although the gene mutated in cystic fibrosis (CFTR) has been cloned and characterized as a chloride channel,...
7.
Brockhausen I, Yang J, Lehotay M, Ogata S, Itzkowitz S
Biol Chem
. 2001 Apr;
382(2):219-32.
PMID: 11308020
The Sialyl-Tn antigen (Sialyl alpha-Ser/Thr) is expressed as a cancer-associated antigen on the surface of cancer cells. Its presence is associated with a poor prognosis in patients with colorectal and...
8.
Dalziel M, Whitehouse C, McFarlane I, Brockhausen I, Gschmeissner S, Schwientek T, et al.
J Biol Chem
. 2000 Dec;
276(14):11007-15.
PMID: 11118434
In breast cancer, the O-glycans added to the MUC1 mucin are core 1- rather than core 2-based. We have analyzed whether competition by the glycosyltransferase, ST3Gal-I, which transfers sialic acid...
9.
10.
Lucien J, Shimada M, Watzka S, Ogiwara M, Brockhausen I, Sandhu J, et al.
Xenotransplantation
. 2000 May;
7(1):21-30.
PMID: 10809054
Discordant xenotransplantation is complicated by delayed xenograft rejection (DXR). Previous studies have demonstrated that anti-apoptotic genes are protective against DXR. This study examines the hypothesis that apoptosis plays a role...