Hye Hyeon Eum
Overview
Explore the profile of Hye Hyeon Eum including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
1681
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Recent Articles
11.
Lee H, Hong Y, Etlioglu H, Cho Y, Pomella V, Van den Bosch B, et al.
Nat Genet
. 2020 May;
52(6):594-603.
PMID: 32451460
Immunotherapy for metastatic colorectal cancer is effective only for mismatch repair-deficient tumors with high microsatellite instability that demonstrate immune infiltration, suggesting that tumor cells can determine their immune microenvironment. To...
12.
Kim N, Kim H, Lee K, Hong Y, Cho J, Choi J, et al.
Nat Commun
. 2020 May;
11(1):2285.
PMID: 32385277
Advanced metastatic cancer poses utmost clinical challenges and may present molecular and cellular features distinct from an early-stage cancer. Herein, we present single-cell transcriptome profiling of metastatic lung adenocarcinoma, the...
13.
Kim N, Chung W, Eum H, Lee H, Park W
PLoS One
. 2019 May;
14(5):e0217196.
PMID: 31100099
Alternative polyadenylation (APA) in 3' untranslated regions (3' UTR) plays an important role in regulating transcript abundance, localization, and interaction with microRNAs. Length-variation of 3'UTRs by APA contributes to efficient...
14.
Han K, Kim K, Joung J, Son D, Kim Y, Jo A, et al.
Genome Res
. 2017 Dec;
28(1):75-87.
PMID: 29208629
Simultaneous sequencing of the genome and transcriptome at the single-cell level is a powerful tool for characterizing genomic and transcriptomic variation and revealing correlative relationships. However, it remains technically challenging...
15.
Chung W, Eum H, Lee H, Lee K, Lee H, Kim K, et al.
Nat Commun
. 2017 May;
8:15081.
PMID: 28474673
Single-cell transcriptome profiling of tumour tissue isolates allows the characterization of heterogeneous tumour cells along with neighbouring stromal and immune cells. Here we adopt this powerful approach to breast cancer...
16.
Kim K, Lee H, Lee H, Kim S, Seo Y, Chung W, et al.
Genome Biol
. 2015 Jun;
16:127.
PMID: 26084335
Background: Intra-tumoral genetic and functional heterogeneity correlates with cancer clinical prognoses. However, the mechanisms by which intra-tumoral heterogeneity impacts therapeutic outcome remain poorly understood. RNA sequencing (RNA-seq) of single tumor...