Hui-Wang Ai
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Explore the profile of Hui-Wang Ai including associated specialties, affiliations and a list of published articles.
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68
Citations
1618
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Recent Articles
1.
Tian X, Zhang Y, Ai H
ACS Chem Biol
. 2024 Dec;
20(1):128-136.
PMID: 39714242
Bioluminescence imaging (BLI) is a powerful, noninvasive imaging method for animal studies. NanoLuc luciferase and its derivatives are attractive bioluminescent reporters recognized for their efficient photon production and ATP independence....
2.
Tian X, Zhang Y, Ai H
bioRxiv
. 2024 May;
PMID: 38746394
NanoLuc luciferase and its derivatives are attractive bioluminescent reporters recognized for their efficient photon production and ATP independence. However, utilizing them for imaging poses notable challenges. Low substrate solubility has...
3.
Zhao S, Xiong Y, Sunnapu R, Zhang Y, Tian X, Ai H
J Am Chem Soc
. 2024 May;
146(19):13406-13416.
PMID: 38698549
Bioluminescent indicators are power tools for studying dynamic biological processes. In this study, we present the generation of novel bioluminescent indicators by modifying the luciferin molecule with an analyte-binding moiety....
4.
Zhao S, Xiong Y, Sunnapu R, Zhang Y, Tian X, Ai H
bioRxiv
. 2024 Apr;
PMID: 38559024
Bioluminescent indicators are power tools for studying dynamic biological processes. In this study, we present the generation of novel bioluminescent indicators by modifying the luciferin molecule with an analyte-binding moiety....
5.
Zhang H, Tian X, Zhang J, Ai H
Biosensors (Basel)
. 2024 Jan;
14(1).
PMID: 38275307
Introducing 3-aminotyrosine (aY), a noncanonical amino acid (ncAA), into green fluorescent protein (GFP)-like chromophores shows promise for achieving red-shifted fluorescence. However, inconsistent results, including undesired green fluorescent species, hinder the...
6.
Zhang J, Li Z, Pang Y, Fan Y, Ai H
ACS Sens
. 2023 Jul;
8(8):2996-3003.
PMID: 37480329
There is great interest in developing boronolectins that are synthetic lectin mimics containing a boronic acid functional group for reversible recognition of diol-containing molecules, such as glycans and ribonucleotides. However,...
7.
Chen C, Zhang H, Zhang J, Ai H, Fang C
Phys Chem Chem Phys
. 2023 May;
25(23):15624-15634.
PMID: 37211909
The incorporation of noncanonical amino acids (ncAAs) into fluorescent proteins is promising for red-shifting their fluorescence and benefiting tissue imaging with deep penetration and low phototoxicity. However, ncAA-based red fluorescent...
8.
Pang Y, Huang M, Fan Y, Yeh H, Xiong Y, Ng H, et al.
ACS Chem Biol
. 2023 May;
18(6):1388-1397.
PMID: 37185019
Boronic acid-containing fluorescent molecules have been widely used to sense hydrogen peroxide and peroxynitrite, which are important reactive oxygen and nitrogen species in biological systems. However, it has been challenging...
9.
Zhang J, Li Z, Pang Y, Fan Y, Ai H
bioRxiv
. 2023 Mar;
PMID: 36909602
There is great interest in developing boronolectins, which are synthetic lectin mimics containing a boronic acid functional group for reversible recognition of diol-containing molecules, such as glycans and ribonucleotides. However,...
10.
Wu T, Kumar M, Zhang J, Zhao S, Drobizhev M, McCollum M, et al.
Sci Adv
. 2023 Mar;
9(9):eadd2058.
PMID: 36857451
Synaptic zinc ion (Zn) has emerged as a key neuromodulator in the brain. However, the lack of research tools for directly tracking synaptic Zn in the brain of awake animals...