Huhu Xin
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Explore the profile of Huhu Xin including associated specialties, affiliations and a list of published articles.
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14
Citations
272
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Recent Articles
1.
Chen Y, Chen X, Zhang Y, Wang M, Yang M, Wang R, et al.
Sci Transl Med
. 2025 Jan;
17(781):eadl5800.
PMID: 39813319
Macrophages play a central role in antitumor immunity, making them an attractive target for gene therapy strategies. However, macrophages are difficult to transfect because of nucleic acid sensors that can...
2.
Zhu C, Ke L, Ao X, Chen Y, Cheng H, Xin H, et al.
Adv Mater
. 2023 Nov;
36(5):e2310078.
PMID: 37947048
Chimeric antigen receptor (CAR)-T cell immunotherapy is approved in the treatment of hematological malignancies, but remains far from satisfactory in solid tumor treatment due to inadequate intra-tumor CAR-T cell infiltration....
3.
Chen X, Wang S, Chen Y, Xin H, Zhang S, Wu D, et al.
Nat Nanotechnol
. 2023 May;
18(8):933-944.
PMID: 37188968
Adoptive T-cell therapy against solid tumours is limited by the apoptosis resistance mechanisms of tumour cells and by the extracellular, immunosuppressive tumour microenvironment. Here we report a temperature-sensitive genome-editing nanodevice...
4.
Shi J, Xin H, Shao Y, Dai S, Tan N, Li Z, et al.
Ann Neurol
. 2023 Apr;
94(1):91-105.
PMID: 37014252
Objective: The precise intervention of K-Cl cotransporter isoform 2 (KCC2) as a promising target for drug-resistant epilepsy remains elusive. Methods: Here, we used a CRISPRa system delivered by adeno-associated viruses...
5.
Xu X, Tang H, Guo J, Xin H, Ping Y
Signal Transduct Target Ther
. 2022 Aug;
7(1):269.
PMID: 35953473
No abstract available.
6.
Yan X, Pan Q, Xin H, Chen Y, Ping Y
Sci Adv
. 2021 Dec;
7(50):eabj0624.
PMID: 34878850
Regulation of CRISPR-Cas9 functions in vivo is conducive to developing precise therapeutic genome editing. Here, we report a CRISPR-Cas9 prodrug nanosystem (termed NanoProCas9), which combines the targeted delivery and the...
7.
Xin H, Huang Y, Tang H, Chen Y, Xia H, Zhang F, et al.
J Mater Chem B
. 2021 Aug;
9(35):7172-7181.
PMID: 34369535
A comprehensive understanding of ferroptosis signaling pathways significantly contributes to the advances in cancer ferrotherapy. Herein, we constructed a self-assembled prodrug nanosystem targeting system x, a key regulator for ferroptosis,...
8.
Guo J, Wan T, Li B, Pan Q, Xin H, Qiu Y, et al.
ACS Cent Sci
. 2021 Jul;
7(6):990-1000.
PMID: 34235260
We synthesized a series of poly(disulfide)s by ring-opening polymerization and demonstrated that the copolymerization of monomer 1 containing diethylenetriamine moieties and monomer 2 containing guanidyl ligands could generate an efficient...
9.
Tang H, Xu X, Chen Y, Xin H, Wan T, Li B, et al.
Adv Mater
. 2021 Feb;
33(12):e2006003.
PMID: 33538047
A photothermal genome-editing strategy is described to improve immune checkpoint blockade (ICB) therapy by CRISPR/Cas9-mediated disruption of PD-L1 and mild-hyperthermia-induced activation of immunogenic cell death (ICD). This strategy relies on...
10.
Chen X, Chen Y, Xin H, Wan T, Ping Y
Proc Natl Acad Sci U S A
. 2020 Jan;
117(5):2395-2405.
PMID: 31941712
We herein report an optogenetically activatable CRISPR-Cas9 nanosystem for programmable genome editing in the second near-infrared (NIR-II) optical window. The nanosystem, termed nanoCRISPR, is composed of a cationic polymer-coated Au...