Hugo Rego Campello
Overview
Explore the profile of Hugo Rego Campello including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
35
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Recent Articles
1.
Maldifassi M, Rego Campello H, Gallagher T, Lester H, Dougherty D
Mol Pharmacol
. 2023 Mar;
103(6):339-347.
PMID: 37001996
Study of 64 nicotinic acetylcholine receptors (nAChRs) as a pharmacological target has recently gained interest because of their involvement in analgesia, control of catecholamine secretion, dopaminergic pathways, and aversive pathways....
2.
Nichols A, Blumenfeld Z, Fan C, Luebbert L, Blom A, Cohen B, et al.
Elife
. 2022 Dec;
11.
PMID: 36520038
No abstract available.
3.
Knox H, Rego Campello H, Lester H, Gallagher T, Dougherty D
J Am Chem Soc
. 2022 Aug;
144(35):16101-16117.
PMID: 36006801
Nicotinic acetylcholine receptors (nAChRs) play an important role in neurotransmission and are also involved in addiction and several disease states. There is significant interest in therapeutic targeting of nAChRs; however,...
4.
Nichols A, Blumenfeld Z, Fan C, Luebbert L, Blom A, Cohen B, et al.
Elife
. 2022 Jan;
11.
PMID: 34982029
Nicotinic partial agonists provide an accepted aid for smoking cessation and thus contribute to decreasing tobacco-related disease. Improved drugs constitute a continued area of study. However, there remains no reductionist...
5.
Davis S, Rego Campello H, Gallagher T, Hunter W
Acta Crystallogr F Struct Biol Commun
. 2020 Feb;
76(Pt 2):74-80.
PMID: 32039888
Cytisine, a natural product with high affinity for clinically relevant nicotinic acetylcholine receptors (nAChRs), is used as a smoking-cessation agent. The compound displays an excellent clinical profile and hence there...
6.
Blom A, Rego Campello H, Lester H, Gallagher T, Dougherty D
J Am Chem Soc
. 2019 Sep;
141(40):15840-15849.
PMID: 31518499
Nicotinic acetylcholine receptors (nAChRs) are crucial for communication between synapses in the central nervous system. As such, they are also implicated in several neuropsychiatric and addictive diseases. Cytisine is a...
7.
Oliveira A, Shoemark D, Rego Campello H, Wonnacott S, Gallagher T, Sessions R, et al.
Structure
. 2019 May;
27(7):1171-1183.e3.
PMID: 31130483
Nicotinic acetylcholine receptors (nAChRs) modulate synaptic transmission in the nervous system. These receptors have emerged as therapeutic targets in drug discovery for treating several conditions, including Alzheimer's disease, pain, and...
8.
Niwetmarin W, Rego Campello H, Sparkes H, Aggarwal V, Gallagher T
Org Biomol Chem
. 2018 Aug;
16(32):5823-5832.
PMID: 30067256
N-Benzyl cytisine undergoes an efficient C(6)-N(7) cleavage via directed C(6) lithiation, borylation and oxidation to provide a "privileged" heterocyclic core unit comprising a highly functionalised, cis-3,5-disubstituted piperidine in enantiomerically pure...
9.
Rego Campello H, Gallagher T
J Org Chem
. 2017 Dec;
83(1):516-520.
PMID: 29207240
(S)-(-)-Cotinine 2 undergoes direct and site-selective iridium-catalyzed borylation to provide boronate ester 3 and bromide 4 which offer flexible entry to a range of C(5)-substituted cotinine variants.
10.
Rego Campello H, Parker J, Perry M, Ryberg P, Gallagher T
Org Lett
. 2016 Aug;
18(16):4124-7.
PMID: 27508307
The ability to affect asymmetric reduction of heterocyclic β-aminoacrylates 1 (n = 1-3) has been assessed with pyrrolidine and piperidone variants generating the corresponding N-heterocyclic β(2)-amino acids 3b and 5b...