Huda H Al-Khalaf
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Explore the profile of Huda H Al-Khalaf including associated specialties, affiliations and a list of published articles.
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24
Citations
409
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Recent Articles
1.
AlAhmari M, Al-Khalaf H, Al-Mohanna F, Ghebeh H, Aboussekhra A
Oncogenesis
. 2020 Aug;
9(8):70.
PMID: 32759946
The AU-rich element RNA-binding protein 1 (AUF1) is an RNA-binding protein, which can both stabilize and destabilize the transcripts of several cancer-related genes. Since epithelial-to-mesenchymal transition (EMT) and the acquisition...
2.
Al-Khalaf H, Ghebeh H, Wakil S, Al-Mohanna F, Aboussekhra A
Mol Cell Biol
. 2020 Feb;
40(9).
PMID: 32015100
During aging, cellular plasticity and senescence play important roles in tissue regeneration and the pathogenesis of different diseases, including cancer. We have recently shown that senescent breast luminal cells can...
3.
Al-Khalaf H, Aboussekhra A
Oncotarget
. 2019 Aug;
10(47):4868-4879.
PMID: 31448053
Osteosarcoma is the most common malignant bone tumor in children, adolescents, and young adults. This pleiomorphic tumor depends on new blood vessel development, also known as angiogenesis, for tumor growth...
4.
Al-Khalaf H, Ghebeh H, Inass R, Aboussekhra A
Mol Cell Biol
. 2018 Nov;
39(2).
PMID: 30397077
Aging and stress promote senescence, which has intrinsic tumor suppressor functions and extrinsic tumor promoting properties. Therefore, it is of utmost importance to delineate the effects of senescence inducers on...
5.
Al-Khalaf H, Al-Harbi B, Al-Sayed A, Arafah M, Tulbah A, Jarman A, et al.
Mol Cell Biol
. 2018 Nov;
39(2).
PMID: 30397072
Increasing evidence supports the critical role of active stromal adipocytes in breast cancer development and spread. However, the mediators and the mechanisms of action are still elusive. We show here...
6.
Al-Khalaf H, Aboussekhra A
Mol Cancer Res
. 2018 May;
16(8):1299-1308.
PMID: 29739873
p16 and p53 are two major tumor suppressor proteins that are both upregulated in response to various cellular stresses and during senescence and aging. p53 is a well-characterized transcription factor,...
7.
Al-Khalaf H, Amir M, Al-Mohanna F, Tulbah A, Al-Sayed A, Aboussekhra A
Mol Cell Biol
. 2017 Jun;
37(17).
PMID: 28630279
Obesity is increasingly recognized as a risk factor for breast cancer development. However, the molecular basis of obesity-related breast carcinogenesis remains elusive. In this study, we have shown that obesity...
8.
Al-Khalaf H, Nallar S, Kalvakolanu D, Aboussekhra A
Mol Carcinog
. 2017 Feb;
56(7):1687-1702.
PMID: 28218424
p16 and p53 are two important tumor suppressor proteins that play essential roles during cell proliferation and aging through regulating the expression of several genes. Here, we report that p16...
9.
Al-Khalaf H, Aboussekhra A
Mol Carcinog
. 2016 Sep;
56(3):985-999.
PMID: 27596953
Senescence and epithelial-to-mesenchymal transition (EMT) processes are under the control of common tumor suppressor proteins, EMT transcription factors, and microRNAs. However, the molecular mechanisms that coordinate the functional link between...
10.
Al-Howail H, Hakami H, Al-Otaibi B, Al-Mazrou A, Daghestani M, Al-Jammaz I, et al.
BMC Cancer
. 2016 Jul;
16:540.
PMID: 27465411
Background: Triple-negative breast cancer (TNBC) is an aggressive histological subtype with limited treatment options and very poor prognosis following progression after standard chemotherapeutic regimens. Therefore, novel molecules and therapeutic options...