Huarui Cui
Overview
Explore the profile of Huarui Cui including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
147
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Recent Articles
1.
Li J, Kirberger S, Wang Y, Cui H, Wagner C, Pomerantz W
Bioconjug Chem
. 2023 Jul;
34(8):1477-1485.
PMID: 37523271
The design of imaging agents with high fluorine content is essential for overcoming the challenges associated with signal detection limits in F MRI-based molecular imaging. In addition to perfluorocarbon and...
2.
Koravovic M, Mayasundari A, Tasic G, Keramatnia F, Stachowski T, Cui H, et al.
Eur J Med Chem
. 2023 Mar;
251:115246.
PMID: 36898329
An X-ray structure of a CLICK chemistry-based BET PROTAC bound to BRD2(BD2) inspired synthesis of JQ1 derived heterocyclic amides. This effort led to the discovery of potent BET inhibitors displaying...
3.
Cui H, Divakaran A, Hoell Z, Ellingson M, Scholtz C, Zahid H, et al.
J Med Chem
. 2022 Jan;
65(3):2342-2360.
PMID: 35007061
Chemical probes for epigenetic proteins are essential tools for dissecting the molecular mechanisms for gene regulation and therapeutic development. The bromodomain and extra-terminal (BET) proteins are master transcriptional regulators. Despite...
4.
Liu M, Cao S, He L, Gao J, Arab J, Cui H, et al.
Nat Commun
. 2021 Jul;
12(1):4560.
PMID: 34315876
Alcoholic hepatitis (AH) is associated with liver neutrophil infiltration through activated cytokine pathways leading to elevated chemokine expression. Super-enhancers are expansive regulatory elements driving augmented gene expression. Here, we explore...
5.
Cui H, Carlson A, Schleiff M, Divakaran A, Johnson J, Buchholz C, et al.
J Med Chem
. 2021 Jul;
64(14):10497-10511.
PMID: 34236185
The bromodomain and extra terminal (BET) protein family recognizes acetylated lysines within histones and transcription factors using two N-terminal bromodomains, D1 and D2. The protein-protein interactions between BET bromodomains, acetylated...
6.
Gao J, Wei B, Liu M, Hirsova P, Sehrawat T, Cao S, et al.
Hepatology
. 2020 Nov;
73(6):2468-2483.
PMID: 33159815
Background And Aims: During liver fibrosis, liver sinusoidal endothelial cells (LSECs) release angiocrine signals to recruit inflammatory cells into the liver. p300, a master regulator of gene transcription, is associated...
7.
Kalra P, McGraw L, Kimbrough J, Pandey A, Solberg J, Cui H, et al.
ACS Chem Biol
. 2020 Nov;
15(11):3038-3049.
PMID: 33138352
Multidomain bromodomain-containing proteins regulate gene expression via chromatin binding, interactions with the transcriptional machinery, and by recruiting enzymatic activity. Selective inhibition of members of the bromodomain and extra-terminal (BET) family...
8.
Cui H, Divakaran A, Pandey A, Johnson J, Zahid H, Hoell Z, et al.
Angew Chem Int Ed Engl
. 2020 Sep;
60(3):1220-1226.
PMID: 32975004
Bromodomain and extra-terminal (BET) family proteins, BRD2-4 and T, are important drug targets; however, the biological functions of each bromodomain remain ill-defined. Chemical probes that selectively inhibit a single BET...
9.
Carlson A, Cui H, Divakaran A, Johnson J, Brunner R, Pomerantz W, et al.
ACS Med Chem Lett
. 2019 Sep;
10(9):1296-1301.
PMID: 31531200
The Bromodomain and Extra Terminal (BET) family of proteins recognize post-translational -ε-acetylated lysine modifications, regulating transcription as "reader" proteins. Bromodomain inhibitors are interesting targets for the development of potential cancer,...
10.
Divakaran A, Talluri S, Ayoub A, Mishra N, Cui H, Widen J, et al.
J Med Chem
. 2018 Sep;
61(20):9316-9334.
PMID: 30253095
As regulators of transcription, epigenetic proteins that interpret post-translational modifications to N-terminal histone tails are essential for maintaining cellular homeostasis. When dysregulated, "reader" proteins become drivers of disease. In the...