Hua-Qun Chen
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Explore the profile of Hua-Qun Chen including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
356
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Recent Articles
1.
Shan X, Zhou N, Pei C, Lu X, Chen C, Chen H
Mol Med
. 2024 Nov;
30(1):218.
PMID: 39548359
Tetrandrine (Tet), a well-known drug of calcium channel blocker, has been broadly applied for anti-inflammatory and anti-fibrogenetic therapy. However, due to the functional diversity of ubiquitous calcium channels, potential side-effects...
2.
Yuan W, Cui C, Li J, Xu Y, Fan C, Chen Y, et al.
iScience
. 2022 Nov;
25(11):105446.
PMID: 36388955
Transmembrane protein 16A (TMEM16A) localizes at plasma membrane and controls chloride influx in various type of cells. We here showed an intracellular localization pattern of TMEM16A molecules. In myoblasts, TMEM16A...
3.
Zhou Y, Sun J, Wang Y, Chen C, Tao T, Ma M, et al.
Proc Natl Acad Sci U S A
. 2022 Jun;
119(26):e2121513119.
PMID: 35737832
Both chronic obstructive pulmonary disease (COPD) and asthma are severe respiratory diseases. Bitter receptor-mediated bronchodilation is a potential therapy for asthma, but the mechanism underlying the agonistic relaxation of airway...
4.
Chen X, Qiu T, Wang Y, Xu L, Sun J, Jiang Z, et al.
J Clin Invest
. 2022 May;
132(14).
PMID: 35617029
Intractable functional constipation (IFC) is the most severe form of constipation, but its etiology has long been unknown. We hypothesized that IFC is caused by refractory infection by a pathogenic...
5.
Zheng Y, Wang Y, Chen X, Wei L, Wang H, Tao T, et al.
J Biol Chem
. 2021 Dec;
298(1):101516.
PMID: 34942145
The thymus is the central immune organ, but it is known to progressively degenerate with age. As thymus degeneration is paralleled by the wasting of aging skeletal muscle, we speculated...
6.
Chen X, Gao Y, Zheng Y, Wang W, Wang P, Liang J, et al.
J Biol Chem
. 2020 May;
295(26):8656-8667.
PMID: 32354746
Mutations in the myotubularin 1 () gene can cause the fatal disease X-linked centronuclear myopathy (XLCNM), but the underlying mechanism is incompletely understood. In this report, using an disease model,...
7.
Wang P, Zhao W, Sun J, Tao T, Chen X, Zheng Y, et al.
J Allergy Clin Immunol
. 2017 Jul;
141(4):1259-1268.e11.
PMID: 28754608
Background: Allergic inflammation has long been implicated in asthmatic hyperresponsiveness of airway smooth muscle (ASM), but its underlying mechanism remains incompletely understood. Serving as G protein-coupled receptor agonists, several inflammatory...
8.
Gao Y, Chen X, Wang P, Lu L, Zhao W, Chen C, et al.
Proc Natl Acad Sci U S A
. 2015 Oct;
112(44):13627-32.
PMID: 26487685
Inheritance of the callipyge phenotype in sheep is an example of polar overdominance inheritance, an unusual mode of inheritance. To investigate the underlying molecular mechanism, we profiled the expression of...
9.
Chen C, Tao T, Wen C, He W, Qiao Y, Gao Y, et al.
J Biol Chem
. 2014 Aug;
289(41):28478-88.
PMID: 25122766
Myosin light chain kinase (MLCK) has long been implicated in the myosin phosphorylation and force generation required for cell migration. Here, we surprisingly found that the deletion of MLCK resulted...
10.
Yu Y, Lv N, Lu Z, Zheng Y, Zhang W, Chen C, et al.
FEBS J
. 2012 Feb;
279(8):1485-94.
PMID: 22353598
There is a current view that myosin light chain kinase (MLCK) plays a critical role in endothelial permeability. To investigate the functions of MLCK in endothelial cells in vivo, we...