Hsin-Yi Chen
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Explore the profile of Hsin-Yi Chen including associated specialties, affiliations and a list of published articles.
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170
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4344
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Recent Articles
1.
Liao E, Law C, Chen H, Wei Y, Tsai Y, Lin L, et al.
Arch Biochem Biophys
. 2025 Feb;
765:110328.
PMID: 39921142
Oral cancer is a malignant tumor, and the associated death rate has significantly increased over the past few decades. Secreted fractions are involved in various physiological processes, and their analysis...
2.
Lipchick B, Guterres A, Chen H, Zundell D, Del Aguila S, Reyes-Uribe P, et al.
Sci Transl Med
. 2025 Feb;
17(784):eadp8913.
PMID: 39908352
Although oncogenic NRAS activates mitogen-activated protein kinase (MAPK) signaling, inhibition of the MAPK pathway is not therapeutically efficacious in -mutant () tumors. Here, we report that selectively silencing the ribosomal...
3.
Shi J, Zhang Z, Chen H, Yao Y, Ke S, Yu K, et al.
Mol Ther
. 2025 Feb;
33(3):1073-1090.
PMID: 39905727
Dysregulation of T cells is a major limitation for the clinical success of T cell-based cancer immunotherapies, such as immune checkpoint blockade and chimeric antigen receptor (CAR)-T cell therapy. Understanding...
4.
Hsu C, Chen H, Hsieh M, Lee Y, Lan C, Yang M
BMC Pulm Med
. 2024 Aug;
24(1):382.
PMID: 39103823
Background: Fiberglass has a larger aerodynamic diameter and is less likely to be inhaled into the lungs. Further, it will be cleared even if it is mechanically broken into smaller...
5.
Wu G, Deng W, Chen H, Cho H, Kim J
Sci Rep
. 2024 Mar;
14(1):6625.
PMID: 38503797
The role of glycan-binding proteins as an activator of immune regulatory receptors has gained attention recently. We report that galectin 7 reduced CD4+ T cell percentage in both in vitro...
6.
He C, Xing X, Chen H, Gao M, Shi J, Xiang B, et al.
Mol Cell
. 2024 Feb;
84(6):1120-1138.e8.
PMID: 38377992
UFMylation is an emerging ubiquitin-like post-translational modification that regulates various biological processes. Dysregulation of the UFMylation pathway leads to human diseases, including cancers. However, the physiological role of UFMylation in...
7.
Chen H, Ko M, Chan H
Biochim Biophys Acta Gen Subj
. 2023 Dec;
1868(2):130538.
PMID: 38072209
Background: Hyperglycemia, which can lead to apoptosis, hypertrophy, fibrosis, and induces hyperinflammation in diabetic vascular complications due to oxidative stress. In order to elucidate the potential dual roles and regulatory...
8.
Lv Q, Chen G, He H, Yang Z, Zhao L, Chen H, et al.
Chem Sci
. 2023 Oct;
14(39):10684-10701.
PMID: 37829020
Traditional Chinese Medicine (TCM) has long been viewed as a precious source of modern drug discovery. AI-assisted drug discovery (AIDD) has been investigated extensively. However, there are still two challenges...
9.
Le T, Chen H, Lam X, Wang C, Chang H
Anal Chem
. 2023 Aug;
95(32):12080-12088.
PMID: 37534668
Nanodiamonds (NDs) are carbon nanoparticles with a large refractive index, a high density, and exceptional chemical stability. When excited by green light, they can emit bright red fluorescence from implanted...
10.
Chen Y, Chen H, Wang W, Chen H, Huang W, Kao C, et al.
Nat Commun
. 2023 May;
14(1):3050.
PMID: 37237031
Activation of tumor-intrinsic innate immunity has been a major strategy for improving immunotherapy. Previously, we reported an autophagy-promoting function of the deubiquitinating enzyme TRABID. Here, we identify a critical role...