Howard S Kruth
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Explore the profile of Howard S Kruth including associated specialties, affiliations and a list of published articles.
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51
Citations
1794
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Recent Articles
1.
Capua-Shenkar J, Varsano N, Itzhak N, Kaplan-Ashiri I, Rechav K, Jin X, et al.
Proc Natl Acad Sci U S A
. 2022 Aug;
119(34):e2205475119.
PMID: 35939716
We employed in a correlative manner an unconventional combination of methods, comprising cathodoluminescence, cryo-scanning electron microscopy (SEM), and cryo-focused ion beam (FIB)-SEM, to examine the volumes of thousands of cubed...
2.
Baumer Y, Dey A, Gutierrez-Huerta C, Khalil N, Sekine Y, Sanda G, et al.
EBioMedicine
. 2020 Jul;
59:102876.
PMID: 32646751
Background: Inflammation plays an important role in the development of cardiovascular disease (CVD). Patients with chronic inflammation diseases have high levels of inflammation and early fatal myocardial infarction due to...
3.
Flores R, Jin X, Chang J, Zhang C, Cogan D, Schaefer E, et al.
Biomolecules
. 2019 Nov;
9(12).
PMID: 31779197
Lecithin:cholesterol acyltransferase (LCAT) is an enzyme secreted by the liver and circulates with high-density lipoprotein (HDL) in the blood. The enzyme esterifies plasma cholesterol and increases the capacity of HDL...
4.
Lucero D, Islam P, Freeman L, Jin X, Pryor M, Tang J, et al.
Biochim Biophys Acta Mol Cell Biol Lipids
. 2019 Nov;
1865(2):158537.
PMID: 31676439
Objective: Highly elevated plasma levels of interleukin-10 (IL-10) are causally associated with "Disappearing HDL Syndrome" and low plasma LDL-cholesterol, but the underlying mechanism is poorly understood. Fluid-phase endocytosis, a process...
5.
Baumer Y, McCurdy S, Jin X, Weatherby T, Dey A, Mehta N, et al.
Atherosclerosis
. 2019 Jun;
287:100-111.
PMID: 31247346
Backgound And Aims: The low-density lipoprotein receptor-deficient (Ldlr) mouse has been utilized by cardiovascular researchers for more than two decades to study atherosclerosis. However, there has not yet been a...
6.
Orekhov A, Oishi Y, Nikiforov N, Zhelankin A, Dubrovsky L, Sobenin I, et al.
Curr Pharm Des
. 2018 Sep;
24(26):3143-3151.
PMID: 30205792
Background: A hallmark of atherosclerosis is its complex pathogenesis, which is dependent on altered cholesterol metabolism and inflammation. Both arms of pathogenesis involve myeloid cells. Monocytes migrating into the arterial...
7.
Orekhov A, Pushkarsky T, Oishi Y, Nikiforov N, Zhelankin A, Dubrovsky L, et al.
Exp Mol Pathol
. 2018 Aug;
105(2):202-207.
PMID: 30118702
High density lipoproteins (HDL) are key components of reverse cholesterol transport pathway. HDL removes excessive cholesterol from peripheral cells, including macrophages, providing protection from cholesterol accumulation and conversion into foam...
8.
Dong F, Jin X, Boettler M, Sciulli H, Abu-Asab M, Del Greco C, et al.
Sci Rep
. 2018 Jul;
8(1):10219.
PMID: 29977031
Schnyder corneal dystrophy (SCD) is a rare autosomal dominant disease in humans, characterized by abnormal deposition of cholesterol and phospholipids in cornea caused by mutations in the UbiA prenyltransferase domain...
9.
Varsano N, Beghi F, Elad N, Pereiro E, Dadosh T, Pinkas I, et al.
Proc Natl Acad Sci U S A
. 2018 Jul;
115(30):7662-7669.
PMID: 29967179
The formation of atherosclerotic plaques in the blood vessel walls is the result of LDL particle uptake, and consequently of cholesterol accumulation in macrophage cells. Excess cholesterol accumulation eventually results...
10.
Jin X, Dimitriadis E, Liu Y, Combs C, Chang J, Varsano N, et al.
Arterioscler Thromb Vasc Biol
. 2018 Jun;
38(7):1504-1518.
PMID: 29853567
Objective: Cells use various mechanisms to maintain cellular cholesterol homeostasis including efflux of cholesterol from the cellular plasma membrane to cholesterol acceptors such as HDLs (high-density lipoproteins). Little is known...