Hong-Yan Guo
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Explore the profile of Hong-Yan Guo including associated specialties, affiliations and a list of published articles.
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Articles
71
Citations
300
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Recent Articles
1.
Sun F, Wang Y, Sun K, Yue F, Sun Y, Ju J, et al.
Mini Rev Med Chem
. 2025 Jan;
PMID: 39851105
Most natural products in nature have broad but not exceedingly good biological activities. The pyrazole structure has been introduced into natural products due to its suitability for various synthetic methods...
2.
Guo H, Tang S, Li L, Lin J, Zhang T, Chao S, et al.
Nat Commun
. 2025 Jan;
16(1):127.
PMID: 39747080
Gestational diabetes mellitus (GDM), a common pregnancy disease, has long-term negative effects on offspring health. Epigenetic changes may have important contributions to that, but the underlying mechanisms are not well...
3.
Ma J, To S, Fung K, Wang K, Zhang J, Ngan A, et al.
Cell Rep
. 2024 Dec;
44(1):115096.
PMID: 39700008
Cancer adhesion to the mesothelium is critical for peritoneal metastasis, but how metastatic cells adapt to the biomechanical microenvironment remains unclear. Our study demonstrates that highly metastatic (HM), but not...
4.
Chao S, Lu J, Li L, Guo H, Xu K, Wang N, et al.
Elife
. 2024 Dec;
13.
PMID: 39642055
Maternal obesity has deleterious effects on the process of establishing oocyte DNA methylation; yet the underlying mechanisms remain unclear. Here, we found that maternal obesity disrupted the genomic methylation of...
5.
Xu F, Xiang Q, Xu M, Carter L, Du W, Zhu C, et al.
Environ Res
. 2024 Nov;
264(Pt 2):120416.
PMID: 39581254
Rising antimicrobial resistance (AMR) is an enormous challenge for global healthcare systems. The effects of elevated CO (eCO) on AMR are poorly characterized. Using a free-air CO enrichment system and...
6.
Xu Q, Deng H, Huang X, Chen G, Quan Y, Wang Y, et al.
Eur J Med Chem
. 2024 Nov;
281:117018.
PMID: 39488969
Natural products play a pivotal role in drug development, including their direct use as pharmaceuticals and their structural modification, yielding molecules with enhanced therapeutic potential. The discovery of bioactive molecules,...
7.
Deng H, Xu Q, Li X, Huang X, Liu J, Yan R, et al.
Eur J Med Chem
. 2024 Sep;
278:116813.
PMID: 39226705
Tumor proliferation and metastasis are intricately linked to blood vessel formation, with vascular endothelial growth factor (VEGF) playing a pivotal role in orchestrating angiogenesis throughout tumor progression. Pseudolaric acid B...
8.
Xu Q, Deng H, Huang X, Liu J, Chen G, Shen Q, et al.
Bioorg Chem
. 2024 Aug;
151:107670.
PMID: 39096560
Pseudolaric Acid B (PAB), a natural product with remarkable anti-tumor activity, is a starting point for new anticancer therapeutics. We designed and synthesized 27 PAB derivatives and evaluated their anti-proliferative...
9.
Wang Y, Guo H, Zhou T, Sun K, Shen Q, Li X
Curr Med Chem
. 2024 Feb;
PMID: 38415438
The current review was undertaken to collate data on Gpx4 inhibitors and the regulatory proteins related to Gpx4. Gpx4 plays an essential role in ferroptosis; it can be used to...
10.
Li H, Miao Y, Suo L, Wang X, Mao Y, Zhang X, et al.
J Cancer
. 2024 Feb;
15(5):1462-1486.
PMID: 38356723
Tumor metastasis is a key factor affecting the life of patients with malignant tumors. For the past hundred years, scientists have focused on how to kill cancer cells and inhibit...