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Hong-Jian Wei

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Articles 25
Citations 365
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Recent Articles
1.
Gallitto M, Zhang X, De Los Santos G, Wei H, Fernandez E, Duan S, et al.
Neuro Oncol . 2024 Oct; 27(3):795-810. PMID: 39394920
Background: Diffuse midline glioma (DMG) is the most aggressive primary brain tumor in children. All previous studies examining the role of systemic agents have failed to demonstrate a survival benefit;...
2.
Zhang X, Duan S, Apostolou P, Wu X, Watanabe J, Gallitto M, et al.
Cancer Discov . 2024 May; 14(9):1732-1754. PMID: 38767413
High-grade gliomas (HGG) are deadly diseases for both adult and pediatric patients. Recently, it has been shown that neuronal activity promotes the progression of multiple subgroups of HGG. However, epigenetic...
3.
Fernandez E, Tomassoni L, Zhang X, Wang J, Obradovic A, Laise P, et al.
bioRxiv . 2024 Apr; PMID: 38559080
Diffuse Midline Gliomas (DMGs) are universally fatal, primarily pediatric malignancies affecting the midline structures of the central nervous system. Despite decades of clinical trials, treatment remains limited to palliative radiation...
4.
Tazhibi M, McQuillan N, Wei H, Gallitto M, Bendau E, Webster Carrion A, et al.
J Transl Med . 2024 Mar; 22(1):320. PMID: 38555449
Background: Diffuse midline glioma (DMG) is a pediatric tumor with dismal prognosis. Systemic strategies have been unsuccessful and radiotherapy (RT) remains the standard-of-care. A central impediment to treatment is the...
5.
Padilla O, Minns H, Wei H, Fan W, Webster-Carrion A, Tazhibi M, et al.
Int J Radiat Oncol Biol Phys . 2024 Feb; 119(4):1248-1260. PMID: 38364947
Purpose: Diffuse midline glioma (DMG) is a fatal tumor traditionally treated with radiation therapy (RT) and previously characterized as having a noninflammatory tumor immune microenvironment (TIME). FLASH is a novel...
6.
Singh A, Peng B, Chien S, Chan C, Deng Y, Pai H, et al.
Biomater Sci . 2023 May; 11(13):4522-4536. PMID: 37158091
Aging involves tissue and cell potential dysfunction characterized by stem cell senescence and extracellular matrix microenvironment (ECM) alteration. Chondroitin sulfate (CS), found in the ECM of normal cells and tissues,...
7.
Lee P, Wei H, Pouliopoulos A, Forsyth B, Yang Y, Zhang C, et al.
ArXiv . 2023 Jan; PMID: 36713234
Focused ultrasound (FUS) can be used to open the blood-brain barrier (BBB), and MRI with contrast agents can detect that opening. However, repeated use of gadolinium-based contrast agents (GBCAs) presents...
8.
Mo Y, Duan S, Zhang X, Hua X, Zhou H, Wei H, et al.
Cancer Discov . 2022 Oct; 12(12):2906-2929. PMID: 36305747
Significance: DMG is a deadly pediatric glioma currently without effective treatments. We discovered that the chromatin remodeler SMARCA4 is essential for the proliferation of DMG with H3K27M mutation in vitro...
9.
Liu C, Zhu N, Sun H, Zhang J, Feng X, Gjerswold-Selleck S, et al.
Front Aging Neurosci . 2022 Aug; 14:923673. PMID: 36034139
While MRI contrast agents such as those based on Gadolinium are needed for high-resolution mapping of brain metabolism, these contrast agents require intravenous administration, and there are rising concerns over...
10.
Englander Z, Wei H, Pouliopoulos A, Bendau E, Upadhyayula P, Jan C, et al.
Sci Rep . 2021 Mar; 11(1):6521. PMID: 33753753
Drug delivery in diffuse intrinsic pontine glioma is significantly limited by the blood-brain barrier (BBB). Focused ultrasound (FUS), when combined with the administration of microbubbles can effectively open the BBB...