Hon C Hui
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Explore the profile of Hon C Hui including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
1379
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Recent Articles
1.
Siegel D, Hui H, Pitts J, Vermillion M, Ishida K, Rautiola D, et al.
J Med Chem
. 2024 Jul;
67(15):12945-12968.
PMID: 39018526
Acute respiratory viral infections, such as pneumovirus and respiratory picornavirus infections, exacerbate disease in COPD and asthma patients. A research program targeting respiratory syncytial virus (RSV) led to the discovery...
2.
Mackman R, Hui H, Perron M, Murakami E, Palmiotti C, Lee G, et al.
J Med Chem
. 2021 Apr;
64(8):5001-5017.
PMID: 33835812
A discovery program targeting respiratory syncytial virus (RSV) identified -nucleoside (RSV A2 EC = 530 nM) as a phenotypic screening lead targeting the RSV RNA-dependent RNA polymerase (RdRp). Prodrug exploration...
3.
Lo M, Jordan R, Arvey A, Sudhamsu J, Shrivastava-Ranjan P, Hotard A, et al.
Sci Rep
. 2017 Mar;
7:43395.
PMID: 28262699
GS-5734 is a monophosphate prodrug of an adenosine nucleoside analog that showed therapeutic efficacy in a non-human primate model of Ebola virus infection. It has been administered under compassionate use...
4.
Siegel D, Hui H, Doerffler E, Clarke M, Chun K, Zhang L, et al.
J Med Chem
. 2017 Jan;
60(5):1648-1661.
PMID: 28124907
The recent Ebola virus (EBOV) outbreak in West Africa was the largest recorded in history with over 28,000 cases, resulting in >11,000 deaths including >500 healthcare workers. A focused screening...
5.
Warren T, Jordan R, Lo M, Ray A, Mackman R, Soloveva V, et al.
Nature
. 2016 Mar;
531(7594):381-5.
PMID: 26934220
The most recent Ebola virus outbreak in West Africa, which was unprecedented in the number of cases and fatalities, geographic distribution, and number of nations affected, highlights the need for...
6.
Mackman R, Ray A, Hui H, Zhang L, Birkus G, Boojamra C, et al.
Bioorg Med Chem
. 2010 Apr;
18(10):3606-17.
PMID: 20409721
GS-9148 [(5-(6-amino-purin-9-yl)-4-fluoro-2,5-dihydro-furan-2-yloxymethyl)phosphonic acid] 4 is a novel nucleoside phosphonate HIV-1 reverse transcriptase (RT) inhibitor with a unique resistance profile toward N(t)RTI resistance mutations. To effectively deliver 4 and its active...
7.
Mackman R, Boojamra C, Prasad V, Zhang L, Lin K, Petrakovsky O, et al.
Bioorg Med Chem Lett
. 2007 Nov;
17(24):6785-9.
PMID: 18029175
A series of nucleoside phosphonate reverse transcriptase (RT) inhibitors have been synthesized and their anti-HIV activity and resistance profiles evaluated. The most potent analog [5-(6-amino-purin-9-yl)-2,5-dihydro-furan-2-yloxymethyl]-phosphonic acid (d4AP) demonstrated a HIV...
8.
Katz B, Elrod K, Verner E, Mackman R, Luong C, Shrader W, et al.
J Mol Biol
. 2003 May;
329(1):93-120.
PMID: 12742021
An extensive structural manifold of short hydrogen bond-mediated, active site-directed, serine protease inhibition motifs is revealed in a set of over 300 crystal structures involving a large suite of small...
9.
Mackman R, Hui H, Breitenbucher J, Katz B, Luong C, Martelli A, et al.
Bioorg Med Chem Lett
. 2002 Jul;
12(15):2019-22.
PMID: 12113832
The development of potent and selective urokinase-type plasminogen activator (uPA) inhibitors based on the lead molecule 2-(2-hydroxy-3-ethoxyphenyl)-1H-benzimidazole-5-carboxamidine (3a) is described.