Holly B Kordasiewicz
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Explore the profile of Holly B Kordasiewicz including associated specialties, affiliations and a list of published articles.
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39
Citations
2635
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Recent Articles
1.
Bunting E, Donaldson J, Cumming S, Olive J, Broom E, Miclaus M, et al.
Sci Transl Med
. 2025 Feb;
17(785):eadn4600.
PMID: 39937881
Expanded CAG alleles in the huntingtin () gene that cause the neurodegenerative disorder Huntington's disease (HD) are genetically unstable and continue to expand somatically throughout life, driving HD onset and...
2.
Mathews E, Coffey S, Gartner A, Belgrad J, Bragg R, OReilly D, et al.
bioRxiv
. 2024 Nov;
PMID: 39574582
Huntington's disease (HD) arises from a CAG expansion in the () gene beyond a critical threshold. A major thrust of current HD therapeutic development is lowering levels of mutant mRNA...
3.
Villar-Pazos S, Thomas L, Yang Y, Chen K, Lyles J, Deitch B, et al.
Nat Commun
. 2023 Oct;
14(1):6547.
PMID: 37848409
PACS1 syndrome is a neurodevelopmental disorder (NDD) caused by a recurrent de novo missense mutation in PACS1 (p.Arg203Trp (PACS1)). The mechanism by which PACS1 causes PACS1 syndrome is unknown, and...
4.
Mortberg M, Gentile J, Nadaf N, Vanderburg C, Simmons S, Dubinsky D, et al.
Nucleic Acids Res
. 2023 May;
51(14):7109-7124.
PMID: 37188501
Antisense oligonucleotides (ASOs) dosed into cerebrospinal fluid (CSF) distribute broadly throughout the central nervous system (CNS). By modulating RNA, they hold the promise of targeting root molecular causes of disease...
5.
Mortberg M, Gentile J, Nadaf N, Vanderburg C, Simmons S, Dubinsky D, et al.
bioRxiv
. 2023 Feb;
PMID: 36824749
Antisense oligonucleotides (ASOs) dosed into cerebrospinal fluid (CSF) distribute broadly throughout the brain and hold the promise of treating myriad brain diseases by modulating RNA. CNS tissue is not routinely...
6.
Villar-Pazos S, Thomas L, Yang Y, Chen K, Lyles J, Deitch B, et al.
Res Sq
. 2023 Feb;
PMID: 36747781
Neurodevelopmental disorders (NDDs) are frequently associated with dendritic abnormalities in pyramidal neurons that affect arbor complexity, spine density, and synaptic communication . The underlying genetic causes are often complex, obscuring...
7.
Fienko S, Landles C, Sathasivam K, McAteer S, Milton R, Osborne G, et al.
Brain
. 2022 Jul;
145(12):4409-4424.
PMID: 35793238
Huntington disease is caused by a CAG repeat expansion in exon 1 of the huntingtin gene (HTT) that is translated into a polyglutamine stretch in the huntingtin protein (HTT). We...
8.
Mortberg M, Zhao H, Reidenbach A, Gentile J, Kuhn E, OMoore J, et al.
JCI Insight
. 2022 Feb;
7(6).
PMID: 35133987
Prion protein (PrP) concentration controls the kinetics of prion replication and is a genetically and pharmacologically validated therapeutic target for prion disease. In order to evaluate PrP concentration as a...
9.
Zhao H, John N, Delic V, Ikeda-Lee K, Kim A, Weihofen A, et al.
Mol Ther Nucleic Acids
. 2021 Aug;
25:152-154.
PMID: 34458000
[This corrects the article DOI: 10.1016/j.omtn.2017.08.002.].
10.
Zhao H, John N, Delic V, Ikeda-Lee K, Kim A, Weihofen A, et al.
Mol Ther Nucleic Acids
. 2021 Jun;
24:1051-1053.
PMID: 34141459
[This corrects the article DOI: 10.1016/j.omtn.2017.08.002.].