Holger Kanzler
Overview
Explore the profile of Holger Kanzler including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
14
Citations
2208
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Milley B, Kiwan R, Ott G, Calacsan C, Kachura M, Campbell J, et al.
Bioconjug Chem
. 2016 Apr;
27(5):1293-304.
PMID: 27074387
We have synthesized and characterized a novel phosphorothioate CpG oligodeoxynucleotide (CpG ODN)-Ficoll conjugated nanoparticulate adjuvant, termed DV230-Ficoll. This adjuvant was constructed from an amine-functionalized-Ficoll, a heterobifunctional linker (succinimidyl-[(N-maleimidopropionamido)-hexaethylene glycol] ester)...
2.
Kachura M, Hickle C, Kell S, Sathe A, Calacsan C, Kiwan R, et al.
J Immunol
. 2015 Nov;
196(1):284-97.
PMID: 26608924
Nanoparticulate delivery systems for vaccine adjuvants, designed to enhance targeting of secondary lymphoid organs and activation of APCs, have shown substantial promise for enhanced immunopotentiation. We investigated the adjuvant activity...
3.
Campbell J, Cho Y, Foster M, Kanzler H, Kachura M, Lum J, et al.
J Clin Invest
. 2009 Sep;
119(9):2564-76.
PMID: 19726873
CpG-containing immunostimulatory DNA sequences (ISS), which signal through TLR9, are being developed as a therapy for allergic indications and have proven to be safe and well tolerated in humans when...
4.
Nicholas Haining W, Davies J, Kanzler H, Drury L, Brenn T, Evans J, et al.
Clin Cancer Res
. 2008 Sep;
14(17):5626-34.
PMID: 18765557
Purpose: CpG oligodeoxynucleotides (CpG-ODN) are being investigated as cancer vaccine adjuvants because they mature plasmacytoid dendritic cells (PDC) into potent antigen-presenting cells. CpG-ODN also induce PDC to secrete chemokines that...
5.
Kanzler H, Barrat F, Hessel E, Coffman R
Nat Med
. 2007 May;
13(5):552-9.
PMID: 17479101
The identification of the antigen recognition receptors for innate immunity, most notably the Toll-like receptors, has sparked great interest in therapeutic manipulation of the innate immune system. Toll-like receptor agonists...
6.
Yarovinsky F, Kanzler H, Hieny S, Coffman R, Sher A
Immunity
. 2006 Sep;
25(4):655-64.
PMID: 17000122
Although Toll-like Receptors (TLRs) play a major function in innate recognition of pathogens, their role in antigen processing and presentation in vivo is poorly understood. Here we establish that Toxoplasma...
7.
Ito T, Kanzler H, Duramad O, Cao W, Liu Y
Blood
. 2005 Nov;
107(6):2423-31.
PMID: 16293610
Recent studies suggest plasmacytoid predendritic cells (pDCs) and myeloid dendritic cells (mDCs) have the functional plasticity to produce similar amounts of type 1 interferons (IFNs) and interleukin-12 (IL-12), challenging the...
8.
Bendriss-Vermare N, Burg S, Kanzler H, Chaperot L, Duhen T, de Bouteiller O, et al.
J Leukoc Biol
. 2005 Aug;
78(4):954-66.
PMID: 16081597
Depending on the activation status, plasmacytoid dendritic cells (PDC) and myeloid DC have the ability to induce CD4 T cell development toward T helper cell type 1 (Th1) or Th2...
9.
Meller S, Winterberg F, Gilliet M, Muller A, Lauceviciute I, Rieker J, et al.
Arthritis Rheum
. 2005 May;
52(5):1504-16.
PMID: 15880822
Objective: To investigate the activation and recruitment pathways of relevant leukocyte subsets during the initiation and amplification of cutaneous lupus erythematosus (LE). Methods: Quantitative real-time polymerase chain reaction was used...
10.
Marshall J, Fearon K, Higgins D, Hessel E, Kanzler H, Abbate C, et al.
DNA Cell Biol
. 2005 Feb;
24(2):63-72.
PMID: 15699627
CpG-C are a novel class of CpG motif-containing immunostimulatory sequences (ISS) that includes both a 5'-TCG element and a CpG-containing palindrome. CpG-C drive all known ISS activities and, in particular,...