Holger Bierhoff
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Explore the profile of Holger Bierhoff including associated specialties, affiliations and a list of published articles.
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26
Citations
1132
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Recent Articles
1.
Bierhoff H, Barber A, Blango M
mBio
. 2024 Sep;
15(10):e0198224.
PMID: 39297713
Molecular communication between host and microbe is mediated by the transfer of many different classes of macromolecules. Recently, the trafficking of RNA molecules between organisms has gained prominence as an...
2.
Bierhoff H
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
. 2024 Apr;
67(5):521-527.
PMID: 38637469
In Germany and worldwide, the average age of the population is continuously rising. With this general increase in chronological age, the focus on biological age, meaning the actual health and...
3.
Reducing the metabolic burden of rRNA synthesis promotes healthy longevity in Caenorhabditis elegans
Sharifi S, Chaudhari P, Martirosyan A, Eberhardt A, Witt F, Gollowitzer A, et al.
Nat Commun
. 2024 Feb;
15(1):1702.
PMID: 38402241
Ribosome biogenesis is initiated by RNA polymerase I (Pol I)-mediated synthesis of pre-ribosomal RNA (pre-rRNA). Pol I activity was previously linked to longevity, but the underlying mechanisms were not studied...
4.
Ren S, Bai F, Schnell V, Stanko C, Ritsch M, Schenk T, et al.
Cell Rep
. 2024 Jan;
43(1):113644.
PMID: 38180837
Extensive remodeling of the female mammary epithelium during development and pregnancy has been linked to cancer susceptibility. The faithful response of mammary epithelial cells (MECs) to hormone signaling is key...
5.
Schnoeder T, Schwarzer A, Jayavelu A, Hsu C, Kirkpatrick J, Dohner K, et al.
Blood
. 2021 Oct;
139(7):1080-1097.
PMID: 34695195
In an effort to identify novel drugs targeting fusion-oncogene-induced acute myeloid leukemia (AML), we performed high-resolution proteomic analysis. In AML1-ETO (AE)-driven AML, we uncovered a deregulation of phospholipase C (PLC)...
6.
Zhao Z, Bierhoff H
Bio Protoc
. 2021 Sep;
7(10):e2285.
PMID: 34541062
The basic unit of chromatin is the nucleosome, a histone octamer with 147 base pairs of DNA wrapped around it. Positions of nucleosomes relative to each other and to DNA...
7.
Greifenstein A, Jo S, Bierhoff H
Essays Biochem
. 2021 Apr;
65(4):731-740.
PMID: 33835128
The genomes of complex eukaryotes largely contain non-protein-coding DNA, which is pervasively transcribed into a plethora of non-coding RNAs (ncRNAs). The functional importance of many of these ncRNAs has been...
8.
Joshi G, Eberhardt A, Lange L, Winkler R, Hoffmann S, Kosan C, et al.
Cancers (Basel)
. 2020 Oct;
12(10).
PMID: 33081395
A major transcriptional output of cells is ribosomal RNA (rRNA), synthesized by RNA polymerase I (Pol I) from multicopy rRNA genes (rDNA). Constitutive silencing of an rDNA fraction by promoter...
9.
Sharifi S, da Costa H, Bierhoff H
Mech Ageing Dev
. 2020 Jun;
189:111282.
PMID: 32531294
Ribosome biogenesis takes place mainly in the nucleolus, a nuclear, non-membrane bound organelle forming around the gene arrays encoding ribosomal RNA (rRNA). Nucleolar activity comprises synthesis, processing and maturation of...
10.
Kofuji S, Hirayama A, Eberhardt A, Kawaguchi R, Sugiura Y, Sampetrean O, et al.
Nat Cell Biol
. 2019 Aug;
21(8):1003-1014.
PMID: 31371825
In many cancers, high proliferation rates correlate with elevation of rRNA and tRNA levels, and nucleolar hypertrophy. However, the underlying mechanisms linking increased nucleolar transcription and tumorigenesis are only minimally...