Holger A Lindner
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Explore the profile of Holger A Lindner including associated specialties, affiliations and a list of published articles.
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39
Citations
735
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Recent Articles
1.
Centner F, Brohm K, Mindt S, Jaeger E, Hahn B, Fuderer T, et al.
Int J Mol Sci
. 2025 Jan;
26(2).
PMID: 39859374
In critically ill patients, compromised microcirculation causes tissue hypoxia, organ failure, and death. These pathophysiological processes occur particularly in patients with high illness severity, so reliable hypoxia biomarkers should reflect...
2.
Guenther T, Coulibaly A, Velasquez S, Schulte J, Fuderer T, Sturm T, et al.
J Inflamm (Lond)
. 2024 Oct;
21(1):40.
PMID: 39434093
Background: Trauma and infection induce emergency granulopoiesis. Counts of immature granulocytes and transcriptional pathways of terminal granulocytic differentiation in blood are elevated in sepsis but correlate with disease severity. This...
3.
Coulibaly A, Sturm T, Schulte J, Lindner H, Velasquez S
STAR Protoc
. 2024 Sep;
5(3):103288.
PMID: 39235937
In human sepsis, myelocytosis and concomitant lymphopenia complicate the study of peripheral blood natural killer (NK) cells. Here, we present a protocol for isolating NK cells from peripheral blood of...
4.
Schoettler J, Brohm K, Mindt S, Jager E, Hahn B, Fuderer T, et al.
Int J Mol Sci
. 2024 Jun;
25(12).
PMID: 38928097
Tissue hypoxia is associated with the development of organ dysfunction and death in critically ill patients commonly captured using blood lactate. The kinetic parameters of serial lactate evaluations are superior...
5.
Velasquez S, Baslar G, Schulte J, Fuderer T, Lindner H, Coulibaly A
Curr Protoc
. 2024 Feb;
4(2):e987.
PMID: 38327104
Natural killer (NK) cells are innate cytokine-producing and cytolytic effector lymphocytes. Their function is responsive to environmental factors, e.g., hypoxia, a frequent feature of inflamed tissues. Such responses require that...
6.
Schaefer N, Lindner H, Hahn B, Schefzik R, Velasquez S, Schulte J, et al.
Front Immunol
. 2024 Jan;
14:1259423.
PMID: 38187375
Background: Pneumonia develops frequently after major surgery and polytrauma and thus in the presence of systemic inflammatory response syndrome (SIRS) and organ dysfunction. Immune checkpoints balance self-tolerance and immune activation....
7.
Centner F, Schoettler J, Brohm K, Mindt S, Jager E, Hahn B, et al.
Int J Mol Sci
. 2023 Aug;
24(16).
PMID: 37628779
A common final pathway of pathogenetic mechanisms in septic organ dysfunction and death is a lack or non-utilization of oxygen. Plasma concentrations of lactate serve as surrogates for the oxygen-deficiency-induced...
8.
Lindner H, Thiel M, Schneider-Lindner V
Lancet Digit Health
. 2023 May;
5(6):e338-e339.
PMID: 37236696
No abstract available.
9.
Velasquez S, Coulibaly A, Sticht C, Schulte J, Hahn B, Sturm T, et al.
Front Immunol
. 2022 Jul;
13:864835.
PMID: 35844509
Infection can induce granulopoiesis. This process potentially contributes to blood gene classifiers of sepsis in systemic inflammatory response syndrome (SIRS) patients. This study aimed to identify signature genes of blood...
10.
Schefzik R, Boland L, Hahn B, Kirschning T, Lindner H, Thiel M, et al.
Front Physiol
. 2022 Jan;
12:801622.
PMID: 35082693
Statistical network analyses have become popular in many scientific disciplines, where an important task is to test for differences between two networks. We describe an overall framework for differential network...