Hiroyuki Unoki
Overview
Explore the profile of Hiroyuki Unoki including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
852
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Recent Articles
1.
Maeda S, Kobayashi M, Araki S, Babazono T, Freedman B, Bostrom M, et al.
PLoS Genet
. 2010 Feb;
6(2):e1000842.
PMID: 20168990
It has been suggested that genetic susceptibility plays an important role in the pathogenesis of diabetic nephropathy. A large-scale genotyping analysis of gene-based single nucleotide polymorphisms (SNPs) in Japanese patients...
2.
Tsukada S, Kobayashi M, Omori S, Unoki H, Maeda S
Diabetes Res Clin Pract
. 2009 Jul;
85(3):279-85.
PMID: 19596470
Aim: We previously identified the transcription factor activating enhancer-binding protein-2beta (AP-2beta) gene as a new candidate for conferring susceptibility to type 2 diabetes. To ascertain the possible involvement of AP-2beta...
3.
Holmkvist J, Banasik K, Andersen G, Unoki H, Jensen T, Pisinger C, et al.
PLoS One
. 2009 Jun;
4(6):e5872.
PMID: 19516902
Background: Polymorphisms in the potassium channel, voltage-gated, KQT-like subfamily, member 1 (KCNQ1) have recently been reported to associate with type 2 diabetes. The primary aim of the present study was...
4.
Unoki H, Takahashi A, Kawaguchi T, Hara K, Horikoshi M, Andersen G, et al.
Nat Genet
. 2008 Aug;
40(9):1098-102.
PMID: 18711366
We conducted a genome-wide association study using 207,097 SNP markers in Japanese individuals with type 2 diabetes and unrelated controls, and identified KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1)...
5.
Kawamura T, Murakami K, Bujo H, Unoki H, Jiang M, Nakayama T, et al.
Exp Biol Med (Maywood)
. 2008 Jul;
233(10):1213-21.
PMID: 18641052
Infiltrated macrophages (Mphi) are believed to cause pathological changes in the surrounding adipocytes through the secretion of active molecules in visceral fat. Matrix metalloproteinase (MMP)-3 is secreted from Mphi, and...
6.
Jiang M, Bujo H, Ohwaki K, Unoki H, Yamazaki H, Kanaki T, et al.
J Clin Invest
. 2008 Jul;
118(8):2733-46.
PMID: 18618022
Medial-to-intimal migration of SMCs is critical to atherosclerotic plaque formation and remodeling of injured arteries. Considerable amounts of the shed soluble form of the LDL receptor relative LR11 (sLR11) produced...
7.
Unoki H, Yamagishi S
Curr Pharm Des
. 2008 May;
14(10):987-9.
PMID: 18473850
Non-enzymatic modification of proteins by reducing sugars, a process that is also known as Maillard reaction, leads to the formation of advanced glycation end products (AGEs) in vivo. There is...
8.
Kubota Y, Unoki H, Bujo H, Rikihisa N, Udagawa A, Yoshimoto S, et al.
Biochem Biophys Res Commun
. 2008 Jan;
368(1):81-7.
PMID: 18201559
The increased population of TLR2/TNF-alpha co-expressing adipocytes is associated with the development of insulin resistance. We have herein shown the significance of low-dose growth hormone (GH) supplementation for the regulation...
9.
Murakami K, Bujo H, Unoki H, Saito Y
Eur J Pharmacol
. 2007 Feb;
561(1-3):206-13.
PMID: 17320860
The relationship between adipocytes and infiltrated macrophages in fat tissue is important for the pathogenesis of insulin resistance through the activation of cytokines. Peroxisome proliferator-activated receptors (PPARs) play a role...
10.
Murakami K, Bujo H, Unoki H, Saito Y
Biochem Biophys Res Commun
. 2007 Feb;
354(3):727-34.
PMID: 17266936
Cytokine production in fat tissue plays a key role in insulin resistance. The aim of study is to know the phenotypic changes of adipocytes with high fat-induced insulin resistance. High...