Hiromichi Sakai
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Explore the profile of Hiromichi Sakai including associated specialties, affiliations and a list of published articles.
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Articles
53
Citations
610
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Recent Articles
1.
Murakami C, Atsuta-Tsunoda K, Inomata S, Kawai T, Hijikata Y, Dilimulati K, et al.
FEBS Lett
. 2025 Feb;
PMID: 39992810
Phosphatidylcholine- and phosphatidylethanolamine-specific phospholipase C (PC-PLC and PE-PLC) activities, which generate diacylglycerol (DG) and are tricyclodecan-9-yl-xanthogenate (D609)-sensitive, have been detected in both the membrane and cytosolic fractions. We have previously...
2.
Sakai H, Murakami C, Takechi M, Urano T, Sakane F
FASEB Bioadv
. 2025 Jan;
7(1):e1481.
PMID: 39781426
Diacylglycerol kinase δ (DGKδ) phosphorylates diacylglycerol to produce phosphatidic acid. Previously, we demonstrated that down-regulation of DGKδ suppresses the myogenic differentiation of C2C12 myoblasts. However, the myogenic roles of DGKδ...
3.
Murakami C, Dilimulati K, Atsuta-Tsunoda K, Kawai T, Inomata S, Hijikata Y, et al.
J Biol Chem
. 2024 Nov;
300(12):107960.
PMID: 39510177
Phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) (EC 3.1.4.3) and phosphatidylethanolamine (PE)-specific PLC (PE-PLC) (EC 3.1.4.62), which generate diacylglycerol (DG) and are tricyclodecan-9-yl-xanthogenate (D609)-sensitive, were detected in detergent-insoluble fractions of mammalian tissues...
4.
Sakane F, Murakami C, Sakai H
Adv Biol Regul
. 2024 Oct;
95:101054.
PMID: 39368888
Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) to produce phosphatidic acid (PA). Mammalian DGK comprise ten isozymes (α-κ) that regulate a wide variety of physiological and pathological events. Recently, we revealed...
5.
Tobita H, Sakai H, Yamaguchi A, Notsu Y, Kataoka M, Yazaki T, et al.
J Clin Biochem Nutr
. 2023 Nov;
73(3):255-261.
PMID: 37970549
Lysophosphatidic acid is composed of lysophosphatidic acid (LPA) molecules with varied chemical forms. The present cross-sectional study was conducted to investigate the associations of various LPA molecules with liver fibrosis....
6.
Sakai H, Okubo M
Yakugaku Zasshi
. 2023 Oct;
143(10):847-855.
PMID: 37779015
In 2006, Japan's pharmaceutical science education was revised to a 6-year enrollment course, placing greater emphasis on cultivating practical clinical ability. Quality Assurance (QA) measures have been implemented including offering...
7.
Haque M, Omori N, Sheikh A, Yano S, Osago H, Mitaki S, et al.
Brain Res
. 2022 Dec;
1800:148197.
PMID: 36481236
Phospholipid levels are reported to be decreased in Alzheimer's disease (AD). For a better understanding, we investigated the time-dependent changes of phospholipids species in a mouse model of AD. The...
8.
Sakai H, Matsumoto K, Urano T, Sakane F
FEBS Open Bio
. 2022 Jul;
12(10):1788-1796.
PMID: 35856166
Effective amelioration of type II diabetes requires therapies that increase both glucose uptake activity per cell and skeletal muscle mass. Myristic acid (14:0) increases diacylglycerol kinase (DGK) δ protein levels...
9.
Azad A, Sheikh A, Haque M, Osago H, Sakai H, Shibly A, et al.
Brain Sci
. 2021 Dec;
11(12).
PMID: 34942905
Plasmalogens are alkenyl-acyl glycerophospholipids and decreased in post-mortem Alzheimer's disease (AD) brains. The aim of this study is to investigate the time-dependent changes of plasmalogens in the hippocampus of an...
10.
Azad A, Kobayashi H, Sheikh A, Osago H, Sakai H, Haque M, et al.
J Mass Spectrom Adv Clin Lab
. 2021 Dec;
22:26-33.
PMID: 34939052
Plasmalogens (Pls) levels are reported to be altered in several neurological and metabolic diseases. Identification of fatty alcohols and fatty acids of different Pls species is necessary to determine the...