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Hiroaki Todo

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Articles 118
Citations 614
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Recent Articles
1.
Yoshida Y, Aoki M, Nagase K, Marubashi K, Kojima H, Itakura S, et al.
Pharmaceutics . 2024 Sep; 16(9). PMID: 39339255
Non-viral mediated plasmid DNA transfection by electroporation (EP) is an established method for gene transfection. In this study, the usefulness of direct EP at an intradermal () site () with...
2.
Nomura M, Tomita J, Itakura S, Todo H, Kodama N, Inoue Y
Drug Dev Ind Pharm . 2024 Jul; 50(7):628-638. PMID: 39030701
Objective: This study was to prepare solid dispersions of lidocaine (Lid) with 5-sulfosalicylic acid dihydrate (SSA) by freeze-drying (freeze-dried [FD] Lid/SSA = 1/1) and to evaluate their physical properties. Methods:...
3.
Kunita R, Nishijima T, Todo H, Miyazawa M
J Toxicol Sci . 2024 May; 49(5):219-230. PMID: 38692909
Quantitative structure permeation relationship (QSPR) models have gained prominence in recent years owing to their capacity to elucidate the influence of physicochemical properties on the dermal absorption of chemicals. These...
4.
Flores K, Okada A, Arce Jr F, See G, Itakura S, Todo H, et al.
Chem Pharm Bull (Tokyo) . 2024 Mar; 72(3):319-323. PMID: 38508724
Auraptene (Aur) is a naturally occurring monoterpene coumarin ether that exhibits numerous therapeutic properties. Its high lipophilicity and low skin penetration, however, limit its potential application for local and transdermal...
5.
Sasaki D, Suzuki H, Kusamori K, Itakura S, Todo H, Nishikawa M
J Nanobiotechnology . 2024 Mar; 22(1):114. PMID: 38493106
Background: Rice bran a by-product of the rice milling process is currently underutilized. Recent studies have shown that plant-derived nanoparticles (pdNPs) can be mass-produced at a low cost and exhibit...
6.
Futaki M, Inamura K, Nishimura T, Niitsu T, Tojo T, Sugibayashi K, et al.
Pharm Res . 2024 Mar; 41(4):819-831. PMID: 38443630
Purpose: Hollow-type microneedles (hMNs) are a promising device for the effective administration of drugs into intradermal sites. Complete insertion of the needle into the skin and administration of the drug...
7.
Inoue Y, Ueda S, Tanikawa T, Sano A, Suzuki R, Todo H, et al.
Foods . 2023 Nov; 12(21). PMID: 37959123
We investigated the physicochemical properties of Japanese rice wines, including their functional properties and carbohydrate and amino acid content in solution and solid state. Three samples were tested. The glucose,...
8.
Takayama K, Itakura S, Todo H, Sugibayashi K
Chem Pharm Bull (Tokyo) . 2023 May; 71(6):386-397. PMID: 37258191
Various stresses and strains are generated on the surface and inside of pharmaceutical tablets when an external force is applied. In addition, stresses in various directions can remain on the...
9.
Futaki M, Inamura K, Hashimoto M, Motegi S, Itakura S, Sugibayashi K, et al.
Pharm Res . 2023 May; 40(8):1953-1963. PMID: 37165148
Purpose: Hollow microneedles (hMNs) have been gaining attention as a tool to enable the intradermal (i.d.) administration of pharmaceutical products. However, few reports have examined the effect of administration volume...
10.
Oshizaka T, Hayakawa M, Uesaka M, Yoshizawa K, Kamei T, Takeuchi I, et al.
Pharm Res . 2023 Apr; 40(6):1577-1586. PMID: 37081304
Purpose: Laurocapram (Azone) was broadly examined as a representative enhancer of skin penetration in the 1980s. However, it was not approved for treatment because it caused skin irritation following its...