Hiren J Joshi
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Explore the profile of Hiren J Joshi including associated specialties, affiliations and a list of published articles.
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42
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2189
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Recent Articles
11.
Bagdonaite I, Pallesen E, Ye Z, Vakhrushev S, Marinova I, Nielsen M, et al.
EMBO Rep
. 2020 Apr;
21(6):e48885.
PMID: 32329196
Post-translational modifications (PTMs) greatly expand the function and potential for regulation of protein activity, and O-glycosylation is among the most abundant and diverse PTMs. Initiation of O-GalNAc glycosylation is regulated...
12.
Narimatsu Y, Joshi H, Nason R, Van Coillie J, Karlsson R, Sun L, et al.
Mol Cell
. 2019 Jun;
75(2):394-407.e5.
PMID: 31227230
The structural diversity of glycans on cells-the glycome-is vast and complex to decipher. Glycan arrays display oligosaccharides and are used to report glycan hapten binding epitopes. Glycan arrays are limited...
13.
Narimatsu Y, Joshi H, Schjoldager K, Hintze J, Halim A, Steentoft C, et al.
Mol Cell Proteomics
. 2019 May;
18(7):1396-1409.
PMID: 31040225
Most proteins trafficking the secretory pathway of metazoan cells will acquire GalNAc-type O-glycosylation. GalNAc-type O-glycosylation is differentially regulated in cells by the expression of a repertoire of up to twenty...
14.
Larsen I, Narimatsu Y, Clausen H, Joshi H, Halim A
Curr Opin Struct Biol
. 2019 Apr;
56:171-178.
PMID: 30999272
Protein O-mannosylation (O-Man), originally discovered in yeast five decades ago, is an important post-translational modification (PTM) conserved from bacteria to humans, but not found in plants or nematodes. Until recently,...
15.
Steentoft C, Fuhrmann M, Battisti F, Van Coillie J, Madsen T, Campos D, et al.
Glycobiology
. 2019 Feb;
29(4):307-319.
PMID: 30726901
Successful application of potent antibody-based T-cell engaging immunotherapeutic strategies is currently limited mainly to hematological cancers. One major reason is the lack of well-characterized antigens on solid tumors with sufficient...
16.
Hintze J, Ye Z, Narimatsu Y, Madsen T, Joshi H, Goth C, et al.
J Biol Chem
. 2018 Oct;
293(49):19064-19077.
PMID: 30327431
The GalNAc-type -glycoproteome is orchestrated by a large family of polypeptide GalNAc-transferase isoenzymes (GalNAc-Ts) with partially overlapping contributions to the -glycoproteome besides distinct nonredundant functions. Increasing evidence indicates that individual...
17.
Bagdonaite I, Vakhrushev S, Joshi H, Wandall H
FEBS Lett
. 2018 Jul;
592(23):3898-3920.
PMID: 29961944
It has long been known that surface proteins of most enveloped viruses are covered with glycans. It has furthermore been demonstrated that glycosylation is essential for propagation and immune evasion...
18.
King S, Goth C, Eckhard U, Joshi H, Haue A, Vakhrushev S, et al.
J Biol Chem
. 2018 Mar;
293(20):7629-7644.
PMID: 29593093
Proteolytic processing is an irreversible post-translational modification functioning as a ubiquitous regulator of cellular activity. Protease activity is tightly regulated via control of gene expression, enzyme and substrate compartmentalization, zymogen...
19.
Joshi H, Hansen L, Narimatsu Y, Freeze H, Henrissat B, Bennett E, et al.
Glycobiology
. 2018 Mar;
28(5):284-294.
PMID: 29579191
Glycosylation of proteins, lipids and proteoglycans in human cells involves at least 167 identified glycosyltransferases (GTfs), and these orchestrate the biosynthesis of diverse types of glycoconjugates and glycan structures. Mutations...
20.
Goth C, Vakhrushev S, Joshi H, Clausen H, Schjoldager K
Trends Biochem Sci
. 2018 Mar;
43(4):269-284.
PMID: 29506880
Limited proteolytic processing is an essential and ubiquitous post-translational modification (PTM) affecting secreted proteins; failure to regulate the process is often associated with disease. Glycosylation is also a ubiquitous protein...