Hiren J Joshi
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Explore the profile of Hiren J Joshi including associated specialties, affiliations and a list of published articles.
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42
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2189
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Recent Articles
1.
Ye Z, Sabatier P, van der Hoeven L, Lechner M, Phlairaharn T, Guzman U, et al.
Nat Methods
. 2025 Jan;
22(3):499-509.
PMID: 39820750
Single-cell proteomics (SCP) promises to revolutionize biomedicine by providing an unparalleled view of the proteome in individual cells. Here, we present a high-sensitivity SCP workflow named Chip-Tip, identifying >5,000 proteins...
2.
Jaroentomeechai T, Karlsson R, Goerdeler F, Teoh F, Gronset M, de Wit D, et al.
Nat Commun
. 2024 Nov;
15(1):9668.
PMID: 39516489
Access to defined glycans and glycoconjugates is pivotal for discovery, dissection, and harnessing of a range of biological functions orchestrated by cellular glycosylation processes and the glycome. We previously employed...
3.
Martinez K, Agirre J, Akune Y, Aoki-Kinoshita K, Arighi C, Axelsen K, et al.
Database (Oxford)
. 2024 Aug;
2024.
PMID: 39137905
Dynamic changes in protein glycosylation impact human health and disease progression. However, current resources that capture disease and phenotype information focus primarily on the macromolecules within the central dogma of...
4.
Bagdonaite I, Abdurahman S, Mirandola M, Pasqual D, Frank M, Narimatsu Y, et al.
J Virol
. 2024 May;
98(6):e0052424.
PMID: 38757972
Ebola virus glycoprotein (EBOV GP) is one of the most heavily O-glycosylated viral glycoproteins, yet we still lack a fundamental understanding of the structure of its large O-glycosylated mucin-like domain...
5.
Larsen I, Povolo L, Zhou L, Tian W, Mygind K, Hintze J, et al.
Proc Natl Acad Sci U S A
. 2023 May;
120(21):e2302584120.
PMID: 37186866
Mutations in the gene cause structural heart defects and renal anomalies syndrome, but the function of the encoded protein remains unknown. We previously reported wide occurrence of O-mannose glycans on...
6.
Nason R, Bull C, Konstantinidi A, Sun L, Ye Z, Halim A, et al.
Nat Commun
. 2021 Jul;
12(1):4070.
PMID: 34210959
Mucins are a large family of heavily O-glycosylated proteins that cover all mucosal surfaces and constitute the major macromolecules in most body fluids. Mucins are primarily defined by their variable...
7.
Macias-Leon J, Bermejo I, Asin A, Garcia-Garcia A, Companon I, Jimenez-Moreno E, et al.
Chem Commun (Camb)
. 2020 Nov;
56(96):15137-15140.
PMID: 33211039
The molecular basis of antibody 5E5, which recognizes the entire GalNAc unit as a primary epitope is disclosed. The antibody's contacts with the peptide are mostly limited to two residues,...
8.
Bull C, Joshi H, Clausen H, Narimatsu Y
STAR Protoc
. 2020 Oct;
1(1):100017.
PMID: 33111073
Exploring the biological functions of the human glycome is highly challenging given its tremendous structural diversity. We have developed stable libraries of isogenic HEK293 cells with loss or gain of...
9.
Schjoldager K, Narimatsu Y, Joshi H, Clausen H
Nat Rev Mol Cell Biol
. 2020 Oct;
21(12):729-749.
PMID: 33087899
Glycosylation is the most abundant and diverse form of post-translational modification of proteins that is common to all eukaryotic cells. Enzymatic glycosylation of proteins involves a complex metabolic network and...
10.
Madsen T, Hansen L, Hintze J, Ye Z, Jebari S, Andersen D, et al.
Nat Commun
. 2020 Aug;
11(1):4033.
PMID: 32820167
Peptide hormones and neuropeptides encompass a large class of bioactive peptides that regulate physiological processes like anxiety, blood glucose, appetite, inflammation and blood pressure. Here, we execute a focused discovery...